CAS 34524-20-4

Boromycin

Description:

Boromycin is a naturally occurring antibiotic that belongs to the class of compounds known as macrolides. It is produced by certain strains of the bacterium *Streptomyces* and is characterized by its complex structure, which includes a boron atom integrated into its molecular framework. This unique feature contributes to its biological activity, particularly its ability to inhibit protein synthesis in bacteria. Boromycin exhibits a broad spectrum of antimicrobial activity, making it effective against various Gram-positive bacteria, including some resistant strains. The compound has garnered interest in medicinal chemistry due to its potential applications in treating bacterial infections. Additionally, boromycin's mechanism of action involves binding to the ribosomal RNA, disrupting the translation process, which is crucial for bacterial growth and reproduction. Its stability and solubility in different solvents also make it a subject of research for further pharmaceutical development. However, like many antibiotics, the emergence of resistance and the need for careful use in clinical settings are important considerations in its application.

Formula: C₄₅H₇₃BNO₁₅·H

InChI: InChI=1/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37?,38?,44+,45+,46?/m1/s1

InChI key: InChIKey=OOBFYEMEQCZLJL-UHFFFAOYSA-O

SMILES: CC1C23[O-][B+3]45[O-]C6(C([O-]4)C(=O)OC(C(OC(C(C(C)C)N)=O)C)CC=CCCC(O)C(C)(C)C(O2)CC1)OC(CCC6C)C(C)(C)C(O)CCCC7CC(OC(=O)C3[O-]5)C(C)O7.[H+]

Synonyms:

• Borate(1-), [1-[1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato-(4-)]-, hydrogen, [T-4-[1R-[1R*,2R*,5S*,6R*,8R*,12R*,14S*,17R*,18R*,19R*,22S*(R*),24Z,28S*,30S*,33R*]]]-
• Borate(1-), [(1R)-1-[(1S,2R,5S,6R,8R,12R,14S,17R,18S,19R,22S,24Z,28S,30S,33R)-1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato(4-)]-, hydrogen, (T-4)-
• Boromycin
• 4,7,21,34,35-Pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacontane, boromycin deriv.
• Borate(1-), [(1R)-1-[(1S,2R,5S,6R,8R,12R,14S,17R,18S,19R,22S,24Z,28S,30S,33R)-1,2,18,19-tetra(hydroxy-κO)-12,28-dihydroxy-6,13,13,17,29,29,33-heptamethyl-3,20-dioxo-4,7,21,34,35-pentaoxatetracyclo[28.3.1.15,8.114,18]hexatriacont-24-en-22-yl]ethyl D-valinato(4-)]-, hydrogen (1:1), (T-4)-

Boromycin

CAS: 34524-20-4

Formula: C₄₅H₇₃BNO₁₅

Purity: ≥99%

Molecular weight: 879.8778

Ref: IN-DA00CQUQ

Boromycin

CAS: 34524-20-4

Boromycin, a boron macrolide from Streptomyces, impedes B. subtilis & B. halodurans, halts cell cycles, and inhibits various HIV strains.

Formula: C₄₅H₇₄BNO₁₅

Color and Shape: Solid

Molecular weight: 879.89

Ref: TM-T36659

Boromycin

CAS: 34524-20-4

Formula: C₄₅H₇₄BNO₁₅

Purity: (TLC) ≥ 99.0%

Color and Shape: Off-white powder

Molecular weight: 879.9

Ref: 7W-GL6068

Boromycin

CAS: 34524-20-4

Boromycin is a macrolide antibiotic, which is derived from the fermentation of certain strains of Streptomyces bacteria. It operates as an ionophore with the ability to transport ions across lipid membranes, effectively disrupting ionic gradients. This mechanism of action compromises essential cellular processes in target organisms, thereby exerting its antimicrobial effects.

Formula: C₄₅H₇₄BNO₁₅

Purity: Min. 95%

Molecular weight: 879.88 g/mol

Ref: 3D-FB171296