CAS 34552-83-5

Loperamide hydrochloride

Description:

Loperamide hydrochloride is an opioid receptor agonist primarily used as an antidiarrheal medication. It works by slowing down gut motility, which increases the time substances stay in the intestines, allowing for more water absorption and resulting in firmer stools. The substance is typically administered in its hydrochloride salt form, enhancing its solubility and stability. Loperamide is characterized by its relatively low bioavailability when taken orally, as it undergoes significant first-pass metabolism in the liver. It is generally well-tolerated, but potential side effects may include constipation, dizziness, and abdominal discomfort. Importantly, loperamide does not penetrate the blood-brain barrier effectively, which minimizes its potential for abuse compared to other opioids. The chemical structure features a piperidine ring, contributing to its pharmacological properties. As with any medication, it is essential to use loperamide as directed to avoid complications, such as toxic megacolon or severe constipation, particularly in cases of bacterial infections.

Formula: C₂₉H₃₃ClN₂O₂·ClH

InChI: InChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key: InChIKey=PGYPOBZJRVSMDS-UHFFFAOYSA-N

SMILES: C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C(N(C)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Synonyms:

• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, hydrochloride
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, monohydrochloride
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, hydrochloride (1:1)
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, monohydrochloride
• 4-(4-(p-Chlorophenyl)-4-hydroxy-1-piperidyl)-N,N-dimethyl-2,2-diphenylbutyramide HCl
• 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenylpiperidine-1-butyramide monohydrochloride
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide HCl
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide monohydrochloride
• 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinobutyramide hydrochloride
• 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride (1:1)
• Arret
• Blox
• Brek
• Dissenten
• Fortasec
• Imodium
• Imodium A-D
• Imodium A-D EZ chews
• Imosec
• Imossel
• Lopemid
• Lopemin
• Loperamide HCl
• Loperazine
• Loperyl
• Lopodium
• Maalox Antidiarrheal
• NSC 696356
• Pj 185
• Pj185
• R 18553
• Suprasec
• Tebloc
• Unii-77Ti35393C
• Up and up anti diarrheal

Loperamide Hydrochloride

CAS: 34552-83-5

Applications Used as an antidiarrheal.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973), Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990),

Formula: C₂₉H₃₃ClN₂O₂·ClH

Color and Shape: White To Off-White

Molecular weight: 513.50

Ref: TR-L469450

Loperamide hydrochloride

Controlled Product

CAS: 34552-83-5

μ-opioid receptor agonist; calcium channel inhibitor; anti-diarrheal

Formula: C₂₉H₃₃ClN₂O₂•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 513.5 g/mol

Ref: 3D-FL24925

Loperamide hydrochloride - Bio-X ™

Controlled Product

CAS: 34552-83-5

Loperamide is an antidiarrheal agent used to control chronic diarrhea causing by inflammatory bowel disease. This drug is a Mu-type opioid receptor agonist and also inhibits the release of prostaglandins and acetylcholine to allow an increase in intestinal transit time.

Formula: C₂₉H₃₄Cl₂N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 513.5 g/mol

Ref: 3D-BL166178