CAS 345891-62-5

Atorvastatin Methyl Ester

Description:

Atorvastatin Methyl Ester, with the CAS number 345891-62-5, is a chemical compound derived from atorvastatin, a widely used statin medication for lowering cholesterol levels. This ester form is characterized by its molecular structure, which includes a methyl ester functional group that influences its solubility and bioavailability. Typically, atorvastatin methyl ester exhibits properties such as being a white to off-white solid, with moderate solubility in organic solvents and limited solubility in water. The compound is known for its pharmacological activity, primarily acting as an inhibitor of HMG-CoA reductase, an enzyme crucial in cholesterol biosynthesis. This inhibition leads to a decrease in cholesterol production in the liver, thereby lowering overall cholesterol levels in the bloodstream. Additionally, atorvastatin methyl ester may undergo hydrolysis in biological systems, reverting to its active form, atorvastatin. As with many pharmaceutical compounds, safety and efficacy are paramount, and its use should be guided by clinical considerations and regulatory standards.

Formula: C₂₂H₁₄D₅ClO₃

InChI: InChI=1/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2/t13-,15+/i7D2,8D2,15D

Atorvastatin Methyl Ester (methyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate)

CAS: 345891-62-5

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

Formula: C₃₄H₃₇FN₂O₅

Color and Shape: White Off-White Solid

Molecular weight: 572.26865

Ref: 45-1A00020

Methyl (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate

CAS: 345891-62-5

Formula: C₃₄H₃₇FN₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 572.6664

Ref: IN-DA00CA16

Atorvastatin EP Impurity K (Atorvastatin Methyl Ester)

CAS: 345891-62-5

Formula: C₃₄H₃₇FN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 572.68

Ref: 4Z-A-136

Atorvastatin Methyl Ester

Controlled Product

CAS: 345891-62-5

Formula: C₃₄H₃₇FN₂O₅

Color and Shape: Neat

Molecular weight: 572.67

Ref: 86-MM0400.02

Atorvastatin Methyl Ester

Controlled Product

CAS: 345891-62-5

Applications Atorvastatin impurity. Atorvastatin Methyl Ester
References Graul, A., et al.: Drugs Future, 22, 956 (1997),

Formula: C₃₄H₃₇FN₂O₅

Color and Shape: White To Off-White

Molecular weight: 572.67

Ref: TR-A791845

Atorvastatin EP Impurity K

CAS: 345891-62-5

Formula: C₃₄H₃₇FN₂O₅

Molecular weight: 572.67

Ref: ST-EA-CP-A32011

Atorvastatin methyl ester

CAS: 345891-62-5

Atorvastatin methyl ester is a statin drug that inhibits the synthesis of cholesterol and other lipids in the body. It is used to reduce high levels of low-density lipoprotein (LDL) cholesterol, which may lead to heart disease or stroke. Atorvastatin methyl ester has been shown to be effective in reducing the uptake of LDL cholesterol into cells by preventing the formation of LDL particles. This drug also decreases the production of biphosphate-containing phospholipids, which are essential for dendritic cell maturation. The crystalline polymorphs have been characterized by X-ray diffraction and microscopy. Impurities can be detected using ultraviolet spectroscopy, infrared spectroscopy, or nuclear magnetic resonance spectroscopy.

Formula: C₃₄H₃₇FN₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 572.67 g/mol

Ref: 3D-IA18021

Atorvastatin methyl ester

CAS: 345891-62-5

Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin.

Formula: C₃₄H₃₇FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 572.67

Ref: TM-T13562