CAS 346-18-9

Polythiazide

Description:

Polythiazide is a thiazide diuretic, primarily used in the treatment of hypertension and edema associated with various medical conditions. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, which helps to lower blood pressure and reduce fluid retention. The chemical structure of polythiazide includes a thiazide ring, which is essential for its diuretic activity. It is typically administered orally and is known for its relatively long duration of action. Common side effects may include electrolyte imbalances, such as hypokalemia, and potential allergic reactions. Polythiazide is often used in combination with other antihypertensive agents to enhance therapeutic efficacy. Its pharmacokinetics involve absorption from the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Overall, polythiazide is an important medication in the management of cardiovascular conditions, contributing to improved patient outcomes when used appropriately.

Formula: C₁₁H₁₃ClF₃N₃O₄S₃

InChI: InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)

InChI key: InChIKey=CYLWJCABXYDINA-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(CSCC(F)(F)F)N1C)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• (.+-.)-Nephril
• (.+-.)-Polythiazide
• 2-Methyl-3-(β,β,β-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
• 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl]thiomethyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
• 6-Chloro-3,4-dihydro-2-methyl-3-[[2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 6-Chloro-3,4-dihydro-2-methyl-7-sulfamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Drenusil
• Nsc 108161
• P 2525
• Politiazida
• Polythiazid
• Renese
• nehpril
• P2525
• 6-chloro-3,4-dihydro-2-methyl-7-sulfamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
• 2-methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
• 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide

Polythiazide

CAS: 346-18-9

Polythiazide

Formula: C₁₁H₁₃ClF₃N₃O₄S₃

Purity: 98.5%

Color and Shape: Off-White To White

Molecular weight: 438.97088

Ref: 47-289

Polythiazide

CAS: 346-18-9

Formula: C₁₁H₁₃ClF₃N₃O₄S₃

Molecular weight: 439.87

Ref: 4Z-P-437001

Polythiazide-13C-d3

CAS: 346-18-9

Formula: C₁₀₁₃CH₁₀D₃ClF₃N₃O₄S₃

Molecular weight: 443.88

Ref: 4Z-P-437004

Polythiazide-d3

Controlled Product

CAS: 346-18-9

Applications Labelled Polythiazide. Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.
References Kaur, J. et al.: J. Ind. Med. Assoc., 48, 13, (1967); Lund-Johansen, P.: Acta Med. Scand., 187, 509 (1970); O'Brien, E.T. et al.: Br. Heart J., 34, 1042 (1972);

Formula: C₁₁H₁₀D₃ClF₃N₃O₄S₃

Color and Shape: Neat

Molecular weight: 442.9

Ref: TR-P689412

Polythiazide

Controlled Product

CAS: 346-18-9

Applications Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.
References Kaur, J. et al.: J. Ind. Med. Assoc., 48, 13, (1967); Lund-Johansen, P.: Acta Med. Scand., 187, 509 (1970); O'Brien, E.T. et al.: Br. Heart J., 34, 1042 (1972);

Formula: C₁₁H₁₃ClF₃N₃O₄S₃

Color and Shape: Off White

Molecular weight: 439.88

Ref: TR-P689410

Polythiazide

CAS: 346-18-9

Color and Shape: Neat

Ref: 61-FOR3231.00