CAS 34604-55-2

3-Hydroxylidocaine

Description:

3-Hydroxylidocaine, with the CAS number 34604-55-2, is a chemical compound that belongs to the class of local anesthetics. It is a derivative of lidocaine, characterized by the presence of a hydroxyl group at the 3-position of the aromatic ring. This modification can influence its pharmacological properties, including its potency and duration of action. 3-Hydroxylidocaine exhibits local anesthetic activity by blocking sodium channels, thereby inhibiting the propagation of nerve impulses. It is typically used in medical applications for its anesthetic effects, particularly in procedures requiring localized pain relief. The compound is generally soluble in organic solvents and has a moderate molecular weight. Its safety profile and potential side effects are similar to those of other local anesthetics, including possible allergic reactions or systemic toxicity if administered improperly. As with all pharmaceuticals, its use should be guided by appropriate medical protocols and regulations.

Formula: C₁₄H₂₂N₂O₂

InChI: InChI=1S/C14H22N2O2/c1-5-16(6-2)9-13(18)15-14-10(3)7-8-12(17)11(14)4/h7-8,17H,5-6,9H2,1-4H3,(H,15,18)

InChI key: InChIKey=PMGUCIDDSCRAMY-UHFFFAOYSA-N

SMILES: N(C(CN(CC)CC)=O)C1=C(C)C(O)=CC=C1C

Synonyms:

• 2-(Diethylamino)-N-(3-hydroxy-2,6-dimethylphenyl)acetamide
• 3-Hydroxy-ω-diethylamino-2,6-dimethylacetanilide
• 3-Hydroxylidocaine
• 3-Hydroxylignocaine
• Acetamide, 2-(diethylamino)-N-(3-hydroxy-2,6-dimethylphenyl)-
• m-Hydroxylidocaine

3'-Hydroxy Lidocaine

CAS: 34604-55-2

Formula: C₁₄H₂₂N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 250.34

Ref: 4Z-L-0614

Lidocaine-3-hydroxy 100 µg/mL in Acetonitrile

CAS: 34604-55-2

Formula: C₁₄H₂₂N₂O₂

Color and Shape: Single Solution

Molecular weight: 250.34

Ref: 04-A14629850AL-100

3-Hydroxy Lidocaine

Controlled Product

CAS: 34604-55-2

Applications A metabolite of Lidocaine (L397800).
References Benowitz, N., et al.: Clin. Pharmacokinet., 3, 177 (1978), Bargetzi, M., et al.: Clin. Pharmacol. Ther., 46, 521 (1989), Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Venkatakrishnan, K., et al.: J. Clin. Pharmacol., 39, 567 (1999), Wang, J., et al.: Pharmacol. Toxicol., 85, 201 (1999),

Formula: C₁₄H₂₂N₂O₂

Color and Shape: Neat

Molecular weight: 250.34

Ref: TR-H943820

3-Hydroxy lidocaine

CAS: 34604-55-2

3-Hydroxy lidocaine is a metabolite of lidocaine and has been shown to be an inhibitor of human serum esterases and other enzymes. It binds to the active site of these enzymes, thereby preventing the hydrolysis of various substrates, including lidocaine. 3-Hydroxy lidocaine has also been shown to be used as an epidural anesthetic in human clinical trials. The pharmacokinetics of 3-hydroxy lidocaine is similar to that of lidocaine with respect to uptake, distribution, and elimination. The metabolism of 3-hydroxy lidocaine is mediated by cytochrome P450 isozyme CYP3A4 which may lead to drug interactions with drugs that are also metabolized by this enzyme system.

Formula: C₁₄H₂₂N₂O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 250.34 g/mol

Ref: 3D-FH24029

3\'-Hydroxy Lidocaine

CAS: 34604-55-2

Formula: C₁₄H₂₂N₂O₂

Molecular weight: 250.3

Ref: ST-EA-CP-L20024

3'-hydroxy Lidocaine

CAS: 34604-55-2

3'-Hydroxy Lidocaine, an active metabolite of Lidocaine, is produced through the metabolism by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.

Formula: C₁₄H₂₂N₂O₂

Color and Shape: Solid

Molecular weight: 250.342

Ref: TM-T85199