CAS 346599-65-3

1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-, hydrochloride (1:1)

Description:

1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-, hydrochloride (1:1), identified by CAS number 346599-65-3, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides, pyrroles, and morpholines. This compound exhibits properties typical of pharmaceuticals, including potential bioactivity due to its ability to interact with biological targets. The presence of halogen substituents, such as chlorine and fluorine, may enhance its pharmacological properties, including lipophilicity and metabolic stability. As a hydrochloride salt, it is likely to be more soluble in water, facilitating its use in biological assays or formulations. The compound's intricate structure suggests potential applications in medicinal chemistry, particularly in the development of therapeutic agents targeting specific diseases. However, detailed studies on its pharmacodynamics, pharmacokinetics, and toxicity are essential for understanding its full potential and safety profile.

Formula: C₂₅H₂₅ClFN₇O₃·ClH

InChI: InChI=1S/C25H25ClFN7O3.ClH/c1-14-10-20(25(36)28-4-5-34-6-8-37-9-7-34)32-19(14)12-16-21-22(29-13-30-23(21)33-24(16)35)31-15-2-3-18(27)17(26)11-15;/h2-3,10-13,32H,4-9H2,1H3,(H,28,36)(H2,29,30,31,33,35);1H

InChI key: InChIKey=CLVDFRRQUCVMJY-UHFFFAOYSA-N

SMILES: C(=C1C2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2NC1=O)C=4NC(C(NCCN5CCOCC5)=O)=CC4C.Cl

Synonyms:

• 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-, monohydrochloride
• 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-, hydrochloride (1:1)

D-69491 hydrochloride

CAS: 346599-65-3

D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.

Formula: C₂₅H₂₆Cl₂FN₇O₃

Color and Shape: Solid

Molecular weight: 562.42

Ref: TM-T201568