CAS 347-66-0

2-Chloro-N-(2-fluorophenyl)acetamide

Description:

2-Chloro-N-(2-fluorophenyl)acetamide, with the CAS number 347-66-0, is an organic compound characterized by its amide functional group, which is derived from acetic acid. This compound features a chloro substituent on the second carbon and a fluorophenyl group, indicating the presence of a fluorine atom on a phenyl ring. The molecular structure contributes to its potential reactivity and biological activity. Typically, compounds of this nature may exhibit properties such as moderate solubility in organic solvents and limited solubility in water, influenced by the presence of halogen atoms which can affect polarity. The chloro and fluoro substituents can also enhance the compound's lipophilicity, potentially impacting its pharmacokinetic properties if used in medicinal chemistry. Additionally, 2-Chloro-N-(2-fluorophenyl)acetamide may serve as an intermediate in the synthesis of various pharmaceuticals or agrochemicals, reflecting its utility in chemical synthesis. Safety data should be consulted for handling and storage, as halogenated compounds can pose specific health and environmental risks.

Formula: C₈H₇ClFNO

InChI: InChI=1S/C8H7ClFNO/c9-5-8(12)11-7-4-2-1-3-6(7)10/h1-4H,5H2,(H,11,12)

InChI key: InChIKey=YHJYFDQKFJQLNL-UHFFFAOYSA-N

SMILES: N(C(CCl)=O)C1=C(F)C=CC=C1

Synonyms:

• N-(2-Fluorophenyl)-2-chloroacetamide
• Acetamide, 2-chloro-N-(2-fluorophenyl)-
• 2-Chloro-N-(2-fluorophenyl)acetamide
• Acetanilide, 2-chloro-2′-fluoro-
• SKL805
• ASISCHEM W60103
• BUTTPARK 30\07-56
• 2-chloro-N-(2-fluorophenyl)ethanamide
• AKOS BBS-00003884
• 2-CHLORO-2'-FLUOROACETANILIDE
• N-(CHLOROACETYL)-2-FLUOROANILINE
• 2-chloro-N-(2-fluorophenyl)acetamide(SALTDATA: FREE)
• AKOS B015620

2-Chloro-N-(2-fluorophenyl)acetamide

CAS: 347-66-0

Formula: C₈H₇ClFNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 187.5987

Ref: IN-DA007BU0

N-(Chloroacetyl)-2-fluoroaniline

CAS: 347-66-0

N-(Chloroacetyl)-2-fluoroaniline

Formula: C₈H₇ClFNO

Purity: ≥95%

Color and Shape: off white to faint beige crystalline solid

Molecular weight: 187.60g/mol

Ref: 54-PC9999

2-chloro-n-(2-fluorophenyl)acetamide

CAS: 347-66-0

2-Chloro-N-(2-fluorophenyl)acetamide (2CPA), also known as activin receptor type IIB (ACTRIIB) antagonist, is an inhibitor of the mitogen activated protein kinase phosphorylation. It has been shown that 2CPA is a selective and potent inhibitor of activin A and activin B, while not inhibiting TGF-β. This drug binds to the ATP site in the activation loop of the kinase domain, preventing phosphorylation by ATP. 2CPA inhibits phosphorylation of both ActRIIA and ActRIIB receptors with IC50 values in the low nanomolar range.

Formula: C₈H₇ClFNO

Purity: Min. 95%

Molecular weight: 187.6 g/mol

Ref: 3D-FC59179

2-Chloro-N-(2-fluorophenyl)acetamide

CAS: 347-66-0

Formula: C₈H₇ClFNO

Purity: 97%

Molecular weight: 187.6

Ref: 10-F039341