CAS 34839-70-8

Metiamide

Description:

Metiamide is a chemical compound that belongs to the class of histamine H2 receptor antagonists, primarily used in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD). It functions by inhibiting the action of histamine at the H2 receptors in the stomach lining, thereby reducing gastric acid secretion. Metiamide is characterized by its ability to provide relief from symptoms associated with excessive stomach acid production. The compound has a relatively low solubility in water, which can affect its bioavailability and absorption in the gastrointestinal tract. Additionally, Metiamide has been noted for its potential side effects, including the risk of agranulocytosis, a serious condition involving a dangerously low white blood cell count. Due to these safety concerns, its clinical use has diminished over time, with newer H2 antagonists being preferred. Overall, Metiamide's role in pharmacology highlights the importance of understanding both therapeutic benefits and potential risks associated with its use.

Formula: C₉H₁₆N₄S₂

InChI: InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)

InChI key: InChIKey=FPBPLBWLMYGIQR-UHFFFAOYSA-N

SMILES: C(SCCNC(NC)=S)C1=C(C)N=CN1

Synonyms:

• 1-Methyl-3-(2-(((4-methyl-1H-imidazol-5-yl)methyl)thio)ethyl)thiourea
• 1-Methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)thiourea
• 1-Methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)thiourea
• 1-Methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea
• 34839-70-8
• N-Methyl-N′-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea
• N-Methyl-N′-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea
• N-Methyl-N′-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]thiourea
• NSC 307755
• Skf 92058
• Thiourea, N-methyl-N′-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-
• thiourea, N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-

Metiamide

CAS: 34839-70-8

Metiamide

Formula: C₉H₁₆N₄S₂

Purity: ≥95%

Molecular weight: 244.38

Ref: 54-BUP02353

Metiamide

CAS: 34839-70-8

Purity: 98%

Ref: IN-DA00C6GI

Metiamide

CAS: 34839-70-8

Metiamide (SK&F 92058) is a histamine H2-receptor antagonist .

Formula: C₉H₁₆N₄S₂

Purity: 97.41%

Color and Shape: Solid

Molecular weight: 244.38

Ref: TM-T7524