CAS 349-88-2

4-Fluorobenzenesulfonyl chloride

Description:

4-Fluorobenzenesulfonyl chloride, with the CAS number 349-88-2, is an organic compound characterized by the presence of a sulfonyl chloride functional group attached to a fluorobenzene ring. It appears as a colorless to pale yellow liquid and is known for its strong reactivity, particularly as a sulfonating agent in organic synthesis. The compound is soluble in organic solvents such as dichloromethane and ether, but it is not soluble in water due to its hydrophobic aromatic structure. It is highly reactive towards nucleophiles, making it useful in the synthesis of sulfonamides and other sulfonyl derivatives. Additionally, 4-fluorobenzenesulfonyl chloride can release toxic gases upon decomposition, necessitating careful handling and storage under inert conditions. Its applications extend to pharmaceuticals and agrochemicals, where it serves as an important intermediate in the development of various chemical entities. As with many sulfonyl chlorides, it is advisable to use appropriate personal protective equipment when working with this compound due to its corrosive nature.

Formula: C₆H₄ClFO₂S

InChI: InChI=1S/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H

InChI key: InChIKey=BFXHJFKKRGVUMU-UHFFFAOYSA-N

SMILES: S(Cl)(=O)(=O)C1=CC=C(F)C=C1

Synonyms:

• 4-Fluoro-Benzenesulfonylchlorid
• 4-Fluorobenzene-1-sulfonyl chloride
• 4-Fluorobenzenesulfonic Acid Chloride
• 4-Fluorobenzenesulfonyl
• 4-Fluorobenzenesulphonyl chloride
• 4-Fluorophenylsulfonyl chloride
• Benzenesulfonyl chloride, 4-fluoro-
• Benzenesulfonyl chloride, p-fluoro-
• NSC 140128
• P-Fluorobenzenesulfonyl chloride
• p-Fluorophenylsulfonyl chloride

4-Fluorobenzenesulfonyl Chloride

CAS: 349-88-2

Formula: C₆H₄ClFO₂S

Purity: >97.0%(GC)(T)

Color and Shape: White or Colorless to Light yellow powder to lump to clear liquid

Molecular weight: 194.60

Ref: 3B-F0202

4-Fluorobenzenesulfonyl chloride, 98%

CAS: 349-88-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₄ClFO₂S

Purity: 98%

Color and Shape: White to cream to pale brown or pale yellow, Powder or crystalline powder or crystals or fused solid

Molecular weight: 194.60

Ref: 02-L07299

4-Fluorobenzene-1-sulfonyl chloride

CAS: 349-88-2

Formula: C₆H₄ClFO₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 194.6112

Ref: IN-DA00341B

4-Fluorobenzenesulphonyl chloride

CAS: 349-88-2

4-Fluorobenzenesulphonyl chloride

Formula: C₆H₄ClFO₂S

Purity: 95%

Color and Shape: white to off-white. crystalline solid

Molecular weight: 194.61g/mol

Ref: 54-PC3490

4-Fluorobenzenesulfonyl chloride

CAS: 349-88-2

Formula: C₆H₄ClFO₂S

Molecular weight: 194.61

Ref: 7W-GK4241

4-Fluorobenzenesulfonyl chloride

CAS: 349-88-2

Formula: C₆H₄ClFO₂S

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 194.6

Ref: 10-F003729

4-Fluorobenzenesulfonyl Chloride

Controlled Product

CAS: 349-88-2

Applications 4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chang, Y.A., et al.: Bioconjugate Chem., 3, 200 (1992); Liao, T.H., et al.: Anal. Biochem., 148, 365 (1985)

Formula: C₆H₄ClFO₂S

Color and Shape: Neat

Molecular weight: 194.61

Ref: TR-F588335

4-Fluorobenzenesulfonyl chloride

CAS: 349-88-2

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell.

Formula: C₆H₄ClFO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 194.61 g/mol

Ref: 3D-FF00435