CAS 34915-68-9

(±)-Bunitrolol

Description:

(±)-Bunitrolol is a beta-blocker with both beta-adrenergic antagonist and partial agonist properties, primarily used in the management of hypertension and certain cardiac conditions. It is characterized by its ability to selectively block beta-1 adrenergic receptors, which are primarily located in the heart, leading to a decrease in heart rate and myocardial contractility. This compound exhibits a racemic mixture, meaning it contains equal parts of two enantiomers, which can exhibit different pharmacological effects. Bunitrolol is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing in clinical settings. Its chemical structure includes a phenolic hydroxyl group and a secondary amine, contributing to its pharmacological activity. Additionally, (±)-Bunitrolol may have some intrinsic sympathomimetic activity, which can influence its overall cardiovascular effects. As with other beta-blockers, potential side effects may include fatigue, dizziness, and bradycardia, and it should be used with caution in patients with respiratory conditions.

Formula: C₁₄H₂₀N₂O₂

InChI: InChI=1S/C14H20N2O2/c1-14(2,3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3

InChI key: InChIKey=VCVQSRCYSKKPBA-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)(C)C)O)C1=C(C#N)C=CC=C1

Synonyms:

• Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-
• Bunitrolol
• 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile
• 1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol
• 1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol

2-(3-(tert-Butylamino)-2-hydroxypropoxy)benzonitrile

CAS: 34915-68-9

Formula: C₁₄H₂₀N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 248.3208

Ref: IN-DA00C98S

Bunitrolol

CAS: 34915-68-9

Applications Bunitrolol is a beta adrenoceptor antagonist that is used as an antihypertensive and antianginal agent.
References Narimatsu, S., et al.: Chirality, 11, 1 (1999); Tsuchihashi, H., et al.: Jpn. J. Pharmacol., 45, 349 (1987)

Formula: C₁₄H₂₀N₂O₂

Color and Shape: Colourless To Light Yellow

Molecular weight: 248.32

Ref: TR-B689440

Bunitrolol-D5

Controlled Product

CAS: 34915-68-9

Applications Bunitrolol-D5 is a labelled analogue of Bunitrolol (B689440).

Formula: C₁₄D₅H₁₅N₂O₂

Color and Shape: Neat

Molecular weight: 253.352

Ref: TR-B689442