CAS 3493-13-8

S-Adenosyl-L-methionine iodide

Description:

S-Adenosyl-L-methionine iodide, commonly referred to as SAMe iodide, is a biologically active compound that plays a crucial role in methyl group transfers in various biochemical processes. It is a derivative of the amino acid methionine and is involved in the synthesis of neurotransmitters, phospholipids, and other important biomolecules. The compound is characterized by its positive charge due to the presence of the iodide ion, which enhances its solubility in aqueous solutions. SAMe iodide is known for its potential therapeutic applications, particularly in the treatment of mood disorders, liver diseases, and osteoarthritis, owing to its role in promoting methylation reactions. The compound is typically stable under physiological conditions but may be sensitive to extreme pH levels and high temperatures. Its biological activity is attributed to its ability to donate methyl groups, influencing gene expression and metabolic pathways. Overall, S-Adenosyl-L-methionine iodide is a significant compound in both biochemistry and pharmacology, with ongoing research exploring its diverse applications.

Formula: C₁₅H₂₃N₆O₅S·I

InChI: InChI=1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key: InChIKey=XQMWYLXPEGFCFT-XKGORWRGSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C[S+](CC[C@@H](C(O)=O)N)C)[C@H]1O.[I-]

Synonyms:

• (3-amino-3-carboxypropyl){[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium iodide (non-preferred name)
• <span class="text-smallcaps">L</span>-Methionine, S-adenosyl-, iodide
• Adenosine, 5′-[(3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, iodide, (3S)-
• Adenosine, 5′-[(<span class="text-smallcaps">L</span>-3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, iodide
• Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, iodide
• Adenosine, 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-, iodide (1:1)
• Methionine, S-adenosyl-, iodide
• S-Adenosyl-<span class="text-smallcaps">L</span>-methionine iodide
• S-Adenosyl-L-Methionine Iodide Salt
• S-Adenosylmethionine iodide
• Adenosine, 5′-[(L-3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, iodide

5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-Adenosine iodide

CAS: 3493-13-8

Formula: C₁₅H₂₃IN₆O₅S

Purity: 80%

Molecular weight: 526.3498

Ref: IN-DA00BZEQ

S-Adenosyl-L-methionine iodide

CAS: 3493-13-8

S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].

Formula: C₁₅H₂₃IN₆O₅S

Color and Shape: Solid

Molecular weight: 526.35

Ref: TM-T74497

S-(5''-Adenosyl)-L-methionine iodide

CAS: 3493-13-8

Ref: 7W-GE8584

S-(5²-Adenosyl)-L-methionine iodide

CAS: 3493-13-8

S-(5²-adenosyl)-L-methionine iodide (SAMMI) is a cytosolic metabolite of the amino acid methionine. It has been found to be immunoreactive in human lung tissue, and its presence is correlated with taurocholate concentration. SAMMI inhibits catechol-O-methyltransferase (COMT), which leads to increased levels of noradrenaline and other catecholamines that are involved in the pathogenesis of lung cancer. SAMMI binds to human lung at the site of injury, leading to ligation of DNA and inhibition of protein synthesis. The effect on protein synthesis is mediated by its ability to repress transcriptional activity through inhibition of RNA polymerase II binding to the promoter regions for genes important in cell proliferation.

Formula: C₁₅H₂₃IN₆O₅S

Purity: 80%Min

Color and Shape: Powder

Molecular weight: 526.35 g/mol

Ref: 3D-DAA49313