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CAS 34973-08-5

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Gonadorelin acetate

Description:
Gonadorelin acetate is a synthetic decapeptide that serves as a gonadotropin-releasing hormone (GnRH) analog. It is primarily used in medical applications to stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland, thereby influencing reproductive functions. The substance is characterized by its ability to mimic the natural GnRH, promoting the regulation of the reproductive hormone axis. Gonadorelin acetate is typically administered via injection and is utilized in various clinical settings, including the treatment of certain types of infertility and in diagnostic procedures for assessing pituitary function. Its chemical structure includes an acetate moiety, which enhances its stability and solubility. The compound is generally well-tolerated, though potential side effects may include headache, flushing, or injection site reactions. As with any peptide hormone, its use is subject to careful medical supervision to ensure efficacy and safety in therapeutic applications.
Formula:C55H75N17O13·C2H4O2
InChI:InChI=1/C55H75N17O13.C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;/m0./s1
SMILES:CC(C)C[C@@H](C(=N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=NCC(=N)O)O)O)N=C(CN=C([C@H](Cc1ccc(cc1)O)N=C([C@H](CO)N=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](Cc1cnc[nH]1)N=C([C@@H]1CCC(=N1)O)O)O)O)O)O)O.CC(=O)O
Synonyms:
  • Gonadelin Acetate
  • Luteinizing hormone-releasing factor (pig), acetate (salt)
  • Cystorelin
  • Fertiline
  • Luprolite acetate
  • Lutrelef
  • Lutrepulse
  • Synthetic luteinizing hormone-releasing factor acetate
  • Luteinizing hormone-releasing factor (swine), acetate (salt)
  • 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-prolylglycinamide acetate (1:1)
  • See more synonyms
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