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CAS 34994-11-1

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Hypusine

Description:
Hypusine is a unique amino acid derivative characterized by its role in cellular processes, particularly in the post-translational modification of proteins. It is formed from the amino acid lysine through a specific enzymatic reaction that involves the addition of a 4-amino-2-hydroxybutyric acid moiety. Hypusine is primarily found in eukaryotic cells, where it is incorporated into the eukaryotic translation initiation factor 5A (eIF5A), which is essential for protein synthesis and cell proliferation. The presence of hypusine is crucial for various biological functions, including cell growth, differentiation, and response to stress. Its synthesis is tightly regulated, and alterations in hypusine levels have been linked to various diseases, including cancer. Hypusine's unique structure and function make it a subject of interest in biochemical research, particularly in understanding its role in translation and potential therapeutic applications.
Formula:C10H23N3O3
InChI:InChI=1S/C10H23N3O3/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16/h8-9,13-14H,1-7,11-12H2,(H,15,16)/t8-,9+/m1/s1
InChI key:InChIKey=BZUIJMCJNWUGKQ-BDAKNGLRSA-N
SMILES:C(CCC[C@@H](C(O)=O)N)NC[C@@H](CCN)O
Synonyms:
  • N6-[(2R)-4-Amino-2-hydroxybutyl]-L-lysine
  • L-Lysine, N6-(4-amino-2-hydroxybutyl)-, (R)-
  • N6-(4-Amino-2-hydroxybutyl)-2,6-diaminohexanoic acid
  • L-Lysine, N6-[(2R)-4-amino-2-hydroxybutyl]-
  • Hypusine
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