CAS 350482-19-8

Buprenorphine-d3

Description:

Buprenorphine-d3 is a deuterated form of buprenorphine, an opioid medication primarily used for pain management and in the treatment of opioid addiction. The "d3" designation indicates that three hydrogen atoms in the buprenorphine molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the substance's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in pharmacokinetic studies and drug metabolism investigations. Buprenorphine itself is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor, which contributes to its analgesic effects and lower potential for abuse compared to full agonists. The chemical structure of buprenorphine-d3 retains the core characteristics of buprenorphine, including its complex ring system and functional groups, while the presence of deuterium allows for more precise tracking in biological studies. As with all opioids, buprenorphine-d3 must be handled with care due to its potential for dependence and side effects.

Formula: C₂₅H₃₂D₃NO₄

InChI: InChI=1S/C25H35NO4/c1-21(2,3)22(4,28)16-13-23-8-9-25(16,29-5)20-24(23)10-11-26-17(23)12-14-6-7-15(27)19(30-20)18(14)24/h6-7,16-17,20,26-28H,8-13H2,1-5H3/t16-,17-,20-,22+,23-,24+,25-/m1/s1/i5D3

InChI key: InChIKey=YOYLLRBMGQRFTN-QLWKBOQPSA-N

SMILES: O(C([2H])([2H])[2H])[C@@]12[C@]3([C@@]45[C@@]([C@@](CC6=C4C(O3)=C(O)C=C6)(NCC5)[H])(C[C@@]1([C@]([C@](C)(C)C)(C)O)[H])CC2)[H]

Synonyms:

• (αS,5α,7α)-α-(1,1-Dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-(methoxy-d3)-α-methyl-6,14-ethenomorphinan-7-methanol
• Buprenorphine-d3
• 6,14-Ethenomorphinan-7-methanol, α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-(methoxy-d3)-α-methyl-, (αS,5α,7α)-

Norbuprenorphine-D3, 0.1mg/ml in Methanol

Controlled Product

CAS: 350482-19-8

Color and Shape: Colourless

Ref: LP-BUP-1355-FB-0.1LM

Norbuprenorphine-D3, 1mg/ml in Methanol

Controlled Product

CAS: 350482-19-8

Color and Shape: Colourless

Ref: LP-BUP-1355-FB-1LM

Norbuprenorphine-D3

Controlled Product

CAS: 350482-19-8

Color and Shape: White

Ref: LP-BUP-1355-FB-10

Norbuprenorphine-d3

Controlled Product

CAS: 350482-19-8

Formula: C₂₅D₃H₃₂NO₄

Color and Shape: Neat

Molecular weight: 416.57

Ref: TR-N661303

Norbuprenorphine-D3 solution

Controlled Product

CAS: 350482-19-8

Norbuprenorphine-D3 solution is a cytotoxic agent that inhibits the production of prostaglandin. It binds to the cysteine residues in the active site of microsomal prostaglandin E synthase and prevents the formation of prostaglandin e2. The histology of norbuprenorphine-D3 solution-treated rats showed marked necrosis and apoptosis, which was confirmed by immunohistochemistry for inducible nitric oxide synthase (iNOS) and terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL). Norbuprenorphine-D3 solution also has anti-inflammatory effects, inhibiting chemokines and inducing damage to viral and bacterial cells.

Formula: C₂₅H₃₂D₃NO₄

Purity: Min. 95%

Molecular weight: 416.57 g/mol

Ref: 3D-APA48219