CAS 351003-38-8

3-(Difluoromethoxy)benzenesulfonyl chloride

Description:

3-(Difluoromethoxy)benzenesulfonyl chloride is an organic compound characterized by its sulfonyl chloride functional group, which is known for its reactivity in various chemical reactions, particularly in the formation of sulfonamides and other sulfonyl derivatives. The presence of the difluoromethoxy group enhances its electrophilic nature, making it a useful intermediate in organic synthesis. This compound typically appears as a colorless to pale yellow liquid or solid, depending on its purity and storage conditions. It is soluble in organic solvents such as dichloromethane and acetone but is generally insoluble in water due to its hydrophobic characteristics. The compound is sensitive to moisture and should be handled with care, as it can release hydrochloric acid upon hydrolysis. Its applications include use in pharmaceuticals, agrochemicals, and as a reagent in various chemical transformations. Proper safety precautions, including the use of personal protective equipment, are essential when working with this compound due to its corrosive nature and potential health hazards.

Formula: C₇H₅ClF₂O₃S

InChI: InChI=1S/C7H5ClF2O3S/c8-14(11,12)6-3-1-2-5(4-6)13-7(9)10/h1-4,7H

InChI key: InChIKey=VKSMJFRQQMGYHS-UHFFFAOYSA-N

SMILES: O(C(F)F)C1=CC(S(Cl)(=O)=O)=CC=C1

Synonyms:

• 3-(Difluoromethoxy)benzenesulphonyl chloride
• 3-(Difluoromethoxy)phenylsulfonyl chloride
• 3-[(Difluoromethyl)oxy]benzenesulfonyl chloride
• Benzenesulfonyl Chloride, 3-(Difluoromethoxy)-
• 3-(Difluoromethoxy)benzenesulfonyl chloride

3-(Difluoromethoxy)benzene-1-sulfonyl chloride

CAS: 351003-38-8

Formula: C₇H₅ClF₂O₃S

Purity: 97%

Color and Shape: Liquid

Molecular weight: 242.6276

Ref: IN-DA003I7N

3-(Difluoromethoxy)benzenesulphonyl chloride

CAS: 351003-38-8

3-(Difluoromethoxy)benzenesulphonyl chloride

Formula: C₇H₅ClF₂O₃S

Purity: ≥95%

Color and Shape: very dark red liquid

Molecular weight: 242.63g/mol

Ref: 54-PC2382

3-(Difluoromethoxy)benzene-1-sulfonyl chloride

CAS: 351003-38-8

Formula: C₇H₅ClF₂O₃S

Purity: ≥97%

Color and Shape: Liquid

Molecular weight: 242.62

Ref: 10-F240194

3-(Difluoromethoxy)benzenesulfonyl Chloride

Controlled Product

CAS: 351003-38-8

Applications 3-(Difluoromethoxy)benzenesulfonyl Chloride is a useful reagent for the preparation of phenoxypyridylpyrimidine derivatives as inositol requiring enzyme 1 (IRE1) activity modulators.
References Braun, M. G., et al.: PCT Int. Appl. (2020), WO 2020056089 A1

Formula: C₇H₅ClF₂O₃S

Color and Shape: Neat

Molecular weight: 242.63

Ref: TR-D447713