CAS 35155-28-3

(8β)-10-Methoxy-1,6-dimethylergoline-8-methanol

Description:

(8β)-10-Methoxy-1,6-dimethylergoline-8-methanol, with the CAS number 35155-28-3, is a chemical compound belonging to the ergoline family, which is characterized by a tetracyclic structure derived from the ergot alkaloids. This compound features multiple functional groups, including methoxy and hydroxymethyl groups, which contribute to its unique chemical properties. Ergoline derivatives are known for their biological activity, often interacting with various neurotransmitter systems, particularly in the central nervous system. The presence of methoxy groups can influence the compound's solubility and reactivity, while the hydroxymethyl group may enhance its potential for hydrogen bonding. Such structural characteristics suggest that (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol could exhibit interesting pharmacological properties, although specific biological activities would require further investigation. As with many ergoline derivatives, safety and toxicity profiles would need to be assessed in any practical applications. Overall, this compound represents a fascinating area of study within medicinal chemistry and pharmacology.

Formula: C₁₈H₂₄N₂O₂

InChI: InChI=1S/C18H24N2O2/c1-19-10-13-7-16-18(22-3,8-12(11-21)9-20(16)2)14-5-4-6-15(19)17(13)14/h4-6,10,12,16,21H,7-9,11H2,1-3H3/t12-,16-,18+/m1/s1

InChI key: InChIKey=LVXVIPZBNJSUKL-NJAPINKUSA-N

SMILES: O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](CO)C2)[H])=CN(C)C4C=CC3

Synonyms:

• (+)-(5R,10S)-Meluol
• (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol
• 1,6-Dimethyl-10-methoxyergoline-8-beta-methanol
• 1,6-Dimethyl-8β-(hydroxymethyl)-10α-methoxyergoline
• 1-Methyl-10α-methoxydihydrolysergol
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol
• 10α-Methoxy-1-methyl-9,10-dihydrolysergol
• 10α-Methoxy-1-methyldihydrolysergol
• Ergoline-8-beta-methanol, 1,6-dimethyl-10-methoxy-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8β)-
• Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
• Lumilysergol, ¹⁰O,1-dimethyl-
• O¹⁰,1-Dimethyllumilysergol
• [(8Beta,10Xi)-10-Methoxy-1,6-Dimethylergolin-8-Yl]Methanol

Nicergoline EP Impurity C

CAS: 35155-28-3

Formula: C₁₈H₂₄N₂O₂

Molecular weight: 300.40

Ref: 4Z-N-070009

Nicergoline EP Impurity C

Controlled Product

CAS: 35155-28-3

Formula: C₁₈H₂₄N₂O₂

Color and Shape: White To Off-White

Molecular weight: 300.40

Ref: 86-MM0115.04

Nicergoline EP Impurity C-N1-13C-d3

CAS: 35155-28-3

Formula: C₁₇₁₃CH₂₁D₃N₂O₂

Molecular weight: 304.41

Ref: 4Z-N-070017

10α-Methoxy-1-methyl-9,10-dihydrolysergol

Controlled Product

CAS: 35155-28-3

Impurity Nicergoline EP Impurity C
Applications 10α-Methoxy-1-methyl-9,10-dihydrolysergol is a nicergoline (N394550) metabolite that has been shown to have antioxidant activity, preventing glutathione (GSH) depletion and lipid peroxidation; thus it has shown potential as treatment of neuroleptic-induced side effects.
References Vairetti, M., et. al.: Eur. J. Pharmacol., 453, 69 (2002)

Formula: C₁₈H₂₄N₂O₂

Color and Shape: White To Off-White

Molecular weight: 300.40

Ref: TR-M262295

10α-Methoxy-1-methyl-d3-9,10-dihydrolysergol

Controlled Product

CAS: 35155-28-3

Applications α-Methoxy-1-methyl-d3-9,10-dihydrolysergol is the labeled analogue of 10α-Methoxy-1-methyl-9,10-dihydrolysergol (M262295), a nicergoline (N394550) metabolite that has been shown to have antioxidant activity, preventing glutathione (GSH) depletion and lipid peroxidation; thus it has shown potential as treatment of neuroleptic-induced side effects.
References Vairetti, M., et. al.: Eur. J. Pharmacol., 453, 69 (2002)

Formula: C₁₈H₂₁D₃N₂O₂

Color and Shape: Neat

Molecular weight: 303.41

Ref: TR-M262297

Nicergoline EP Impurity C

CAS: 35155-28-3

Formula: C₁₈H₂₄N₂O₂

Molecular weight: 300.4

Ref: ST-EA-CP-N40003