CAS 35180-01-9

Chloromethyl 1-methylethyl carbonate

Description:

Chloromethyl 1-methylethyl carbonate, with the CAS number 35180-01-9, is an organic compound characterized by its carbonate functional group and the presence of a chloromethyl substituent. This compound typically appears as a colorless to pale yellow liquid and is known for its moderate volatility. It is soluble in organic solvents but has limited solubility in water. The presence of the carbonate group suggests that it may participate in various chemical reactions, including nucleophilic substitutions and polymerization processes. Chloromethyl 1-methylethyl carbonate can be used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Safety considerations are important when handling this compound, as it may be irritant to skin and eyes and could pose health risks if inhaled or ingested. Proper storage and handling protocols should be followed to minimize exposure and ensure safe usage in laboratory or industrial settings.

Formula: C₅H₉ClO₃

InChI: InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3

InChI key: InChIKey=JHYNXXBAHWPABC-UHFFFAOYSA-N

SMILES: O(C(OCCl)=O)C(C)C

Synonyms:

• CMIC,for Tenofovir
• Carbonic acid, chloromethyl 1-methylethyl ester
• Chloromethyl 1-methylethyl carbonate
• Chloromethyl Propan-2-Yl Carbonate
• Chloromethyl propyl carbonate
• Chloromethyl-2-propyl Carbonate
• Isopropoxycarbonyloxymethyl chloride
• Isopropyl chloromethyl carbonate
• [(Isopropyloxycarbonyl)oxy]methyl chloride
• i-Propyl Chloromethyl Carbonate
• Chloromethyl isopropyl carbonate

Chloromethyl Isopropyl Carbonate

CAS: 35180-01-9

Formula: C₅H₉ClO₃

Purity: >98.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 152.57

Ref: 3B-C2626

Chloromethyl Isopropyl Carbonate

CAS: 35180-01-9

Esters of other inorganic acids of nonmetals & their salts, their halogenated/sulfonated/nitrated/nitrosated derivs, except of hydrogen halides, nesoi

Formula: C₅H₉ClO₃

Color and Shape: Colorless Liquid

Molecular weight: 152.02402

Ref: 45-1115705

Isopropyl chloromethyl carbonate

CAS: 35180-01-9

Formula: C₅H₉ClO₃

Purity: 98%

Color and Shape: Liquid

Molecular weight: 152.5762

Ref: IN-DA0034LN

Chloromethyl isopropyl carbonate

CAS: 35180-01-9

Chloromethyl isopropyl carbonate

Purity: 99%

Molecular weight: 152.58g/mol

Ref: 54-OR905009

Tenofovir Impurity 56

CAS: 35180-01-9

Formula: C₅H₉ClO₃

Molecular weight: 152.57

Ref: 4Z-T-02100

Chloromethyl Isopropyl Carbonate

Controlled Product

CAS: 35180-01-9

Stability Moisture sensitive
Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),

Formula: C₅H₉ClO₃

Color and Shape: Neat

Molecular weight: 152.58

Ref: TR-C369230

Chloromethyl isopropyl carbonate

CAS: 35180-01-9

Formula: C₅H₉ClO₃

Purity: 98%

Color and Shape: Liquid

Molecular weight: 152.57

Ref: 10-F239635

Chloromethyl isopropyl carbonate

CAS: 35180-01-9

Chloromethyl isopropyl carbonate (CIC) is a prodrug that is converted to disoproxil in the body. It has significant cytotoxicity and antiviral activity against HIV and other viruses, but has not been used clinically due to its chemical instability. CIC can be administered orally as a prodrug, with the active form of CIC being tenofovir disoproxil. Tenofovir disoproxil is metabolized by proximal tubules and has shown efficacy for treating hepatitis B and C. Tenofovir has also been shown to decrease the incidence of renal disease in HIV patients.

Formula: C₅H₉ClO₃

Purity: Min. 95%

Color and Shape: Colorless Powder

Molecular weight: 152.58 g/mol

Ref: 3D-FC20252