CAS 351862-32-3

Sarizotan

Description:

Sarizotan is a chemical compound that functions primarily as a selective serotonin and dopamine receptor agonist. It is known for its potential applications in treating conditions such as Parkinson's disease and other neurological disorders. Sarizotan exhibits a unique pharmacological profile, acting on both serotonin (5-HT) and dopamine receptors, which may contribute to its therapeutic effects. The compound is characterized by its ability to modulate neurotransmitter activity, potentially improving motor function and reducing symptoms associated with dopamine deficiency. Additionally, Sarizotan has been studied for its effects on sleep regulation and anxiety, highlighting its multifaceted role in the central nervous system. Its chemical structure includes specific functional groups that facilitate its interaction with receptor sites, influencing its efficacy and safety profile. As with many pharmacological agents, ongoing research continues to explore its full therapeutic potential and any associated side effects.

Formula: C₂₂H₂₁FN₂O

InChI: InChI=1S/C22H21FN2O/c23-20-8-5-17(6-9-20)19-11-16(12-24-14-19)13-25-15-21-10-7-18-3-1-2-4-22(18)26-21/h1-6,8-9,11-12,14,21,25H,7,10,13,15H2/t21-/m1/s1

InChI key: InChIKey=HKFMQJUJWSFOLY-OAQYLSRUSA-N

SMILES: C(NC[C@@H]1OC=2C(CC1)=CC=CC2)C3=CC(=CN=C3)C4=CC=C(F)C=C4

Synonyms:

• 3-Pyridinemethanamine, N-[[(2R)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-5-(4-fluorophenyl)-
• N-[[(2R)-3,4-Dihydro-2H-1-benzopyran-2-yl]methyl]-5-(4-fluorophenyl)-3-pyridinemethanamine
• Sarizotan

(R)-1-(Chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine

CAS: 351862-32-3

(R)-1-(Chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine

Purity: 98%

Molecular weight: 348.42g/mol

Ref: 54-PC1007725

Sarizotan

CAS: 351862-32-3

Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.

Formula: C₂₂H₂₁FN₂O

Color and Shape: Solid

Molecular weight: 348.421

Ref: TM-T40439