CAS 352457-33-1

6-Chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2-methyl-4(1H)-pyrimidinone

Description:

6-Chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2-methyl-4(1H)-pyrimidinone, with CAS number 352457-33-1, is a chemical compound that belongs to the class of pyrimidinones. This substance features a pyrimidine ring substituted with a chlorine atom and an amino group linked to a dihydroimidazole moiety, which contributes to its biological activity. It is characterized by its potential as a pharmacological agent, often investigated for its role in medicinal chemistry, particularly in the development of therapeutic agents targeting various diseases. The presence of the imidazole ring suggests possible interactions with biological targets, making it of interest in drug discovery. The compound's solubility, stability, and reactivity can vary based on environmental conditions and the presence of other chemical entities. As with many heterocyclic compounds, its structure allows for diverse modifications, which can enhance its efficacy and selectivity in biological applications. Safety and handling precautions should be observed, as with all chemical substances, due to potential toxicity or reactivity.

Formula: C₈H₁₀ClN₅O

InChI: InChI=1S/C8H10ClN5O/c1-4-12-6(9)5(7(15)13-4)14-8-10-2-3-11-8/h2-3H2,1H3,(H2,10,11,14)(H,12,13,15)

InChI key: InChIKey=DPGWPFBOPWMOBR-UHFFFAOYSA-N

SMILES: N(C1=C(Cl)NC(C)=NC1=O)C=2NCCN2

Synonyms:

• 6-Chloro-5-[(imidazolidin-2-ylidene)amino]-2-methylpyrimidin-4-ol
• 6-Chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2-methyl-4(1H)-pyrimidinone
• 4(1H)-Pyrimidinone, 6-chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2-methyl-
• Moxonidine Impurity 4 (Moxonidine EP Impurity D)
• Reaxys ID: 26020852
• 6-O-DesMethyl Moxonidine
• Moxonidine Impurity D
• Moxonidine EP impurity D

Moxonidine EP Impurity D

CAS: 352457-33-1

Formula: C₈H₁₀ClN₅O

Color and Shape: White To Off-White Solid

Molecular weight: 227.65

Ref: 4Z-M-371

6-O-Desmethyl Moxonidine

Controlled Product

CAS: 352457-33-1

Stability Hygroscopic and Light Sensitive
Applications 6-O-Desmethyl Moxonidine is an impurity of the antihypertensive agent, Moxonidine (M745800).
References Milovanovic, S. et al.: J. Pharmac. Biomed. Anal., 59, 151 (2012);

Formula: C₈H₁₀ClN₅O

Color and Shape: Neat

Molecular weight: 227.65

Ref: TR-D291940

6-o-Desmethyl moxonidine

CAS: 352457-33-1

6-O-Desmethyl moxonidine is a drug product that is a metabolite of the parent compound, moxonidine. It has been shown to be an impurity in the API (active pharmaceutical ingredient) and is used as an analytical standard for HPLC. 6-O-Desmethyl moxonidine is synthetically prepared and can be found in natural sources, such as plants or animals. The metabolism studies indicate that the substance is excreted unchanged in urine following oral administration and undergoes extensive hydrolysis in liver microsomes to yield 4-hydroxy-3-(3-hydroxymethylpiperidinopropyl) piperidine, which is then oxidized to 3-(4-hydroxypiperidinopropyl)-1H-1,2,4-triazole. This product may cause skin irritation.

Formula: C₈H₁₀ClN₅O

Purity: Min. 95%

Molecular weight: 227.65 g/mol

Ref: 3D-CPA45733