CAS 352513-83-8

Semapimod

Description:

Semapimod, with the CAS number 352513-83-8, is a chemical compound that functions primarily as an immunomodulator. It is known for its role in modulating the immune response, particularly in the context of inflammatory diseases. Semapimod acts as a selective inhibitor of certain signaling pathways, specifically targeting the p38 mitogen-activated protein kinase (MAPK) pathway, which is crucial in the regulation of inflammatory processes. This inhibition can lead to a reduction in the production of pro-inflammatory cytokines, making it a potential therapeutic agent for conditions characterized by excessive inflammation. The compound is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. Semapimod has been studied in various preclinical and clinical settings, showcasing its potential benefits in treating autoimmune disorders and other inflammatory conditions. However, as with any pharmacological agent, its efficacy and safety profile are subject to ongoing research and evaluation.

Formula: C₃₄H₅₂N₁₈O₂

InChI: InChI=1S/C34H52N18O2/c1-19(45-49-31(35)36)23-13-24(20(2)46-50-32(37)38)16-27(15-23)43-29(53)11-9-7-5-6-8-10-12-30(54)44-28-17-25(21(3)47-51-33(39)40)14-26(18-28)22(4)48-52-34(41)42/h13-18H,5-12H2,1-4H3,(H,43,53)(H,44,54)(H4,35,36,49)(H4,37,38,50)(H4,39,40,51)(H4,41,42,52)

InChI key: InChIKey=PWDYHMBTPGXCSN-UHFFFAOYSA-N

SMILES: C(=NNC(=N)N)(C)C1=CC(C(=NNC(=N)N)C)=CC(NC(CCCCCCCCC(NC2=CC(C(=NNC(=N)N)C)=CC(C(=NNC(=N)N)C)=C2)=O)=O)=C1

Synonyms:

• N1,N10-Bis[3,5-bis[1-[2-(aminoiminomethyl)hydrazinylidene]ethyl]phenyl]decanediamide
• Semapimod
• Decanediamide, N,N′-bis[3,5-bis[1-[(aminoiminomethyl)hydrazono]ethyl]phenyl]-
• CPSI 2364
• Decanediamide, N1,N10-bis[3,5-bis[1-[2-(aminoiminomethyl)hydrazinylidene]ethyl]phenyl]-

Semapimod

CAS: 352513-83-8

Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6.

Formula: C₃₄H₅₂N₁₈O₂

Color and Shape: Solid

Molecular weight: 744.9

Ref: TM-T79304