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CAS 352523-15-0

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Fmoc-D-2-Trifluoromethylphe

Description:
Fmoc-D-2-Trifluoromethylphenylalanine, commonly referred to as Fmoc-D-2-Trifluoromethylphe, is a synthetic amino acid derivative used primarily in peptide synthesis and research. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The presence of the trifluoromethyl group enhances the compound's lipophilicity and can influence the biological activity and stability of peptides. This compound is typically utilized in solid-phase peptide synthesis (SPPS), where it aids in the formation of peptides with specific sequences and properties. Its unique structural features contribute to its utility in medicinal chemistry and drug development, particularly in the design of compounds with enhanced pharmacological profiles. As with many fluorinated compounds, Fmoc-D-2-Trifluoromethylphe may exhibit distinct solubility and reactivity characteristics compared to its non-fluorinated counterparts, making it a valuable tool in the synthesis of novel peptides and therapeutic agents.
Formula:C25H20F3NO4
InChI:InChI=1/C25H20F3NO4/c26-25(27,28)21-12-6-1-7-15(21)13-22(23(30)31)29-24(32)33-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,29,32)(H,30,31)/t22-/m1/s1
SMILES:c1ccc(c(c1)C[C@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12)C(F)(F)F
Synonyms:
  • Fmoc-2-Trifluoromethyl-D-phenylalanine
  • Fmoc-D-2-Trifluoromethylphenylalanine
  • FMOC-D-2-TRIFLUOROMETHYLPHE
  • (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2-(trifluoromethyl)phenyl)propanoic acid
  • FMOC-D-2-TRIFLUOROMETHYL-PHE-OH
  • RARECHEM BK PT 0132
  • FMOC-D-PHE(2-TRIFLUOROMETHYL)-OH
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-2TRIFLUOROPHENYLALANINE
  • (R)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
  • FMOC-D-PHE(2-CF 3)-OH
  • 2-(Trifluoromethyl)-D-phenylalanine,N-FMOCprotected
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