CAS 352523-18-3

7-Ketocholesteryl-9-carboxynonanoate

Description:

7-Ketocholesteryl-9-carboxynonanoate is a synthetic derivative of cholesterol, characterized by the presence of a ketone group at the 7-position and a carboxylic acid moiety linked to a nonanoate chain. This compound is notable for its amphiphilic nature, which allows it to interact with both hydrophilic and hydrophobic environments, making it relevant in various biochemical applications. It is often studied in the context of lipid metabolism and cellular signaling due to its structural similarity to cholesterol, which plays a crucial role in cell membrane integrity and function. The presence of the carboxynonanoate group may influence its solubility and biological activity, potentially affecting its interactions with proteins and membranes. Additionally, compounds like 7-Ketocholesteryl-9-carboxynonanoate are of interest in research related to atherosclerosis and other lipid-related diseases, as they can serve as markers or modulators in lipid metabolism pathways. As with many synthetic compounds, safety and handling precautions should be observed, given its potential biological effects.

Formula: C₃₆H₅₈O₅

Synonyms:

• Cholest-5-en-7-one, 3-[(8-carboxy-1-oxooctyl)oxy]-, (3β)-
• oxLig-1
• 7-Ketocholesteryl-9-carboxynonanoate

oxLig-1

CAS: 352523-18-3

OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).

Formula: C₃₆H₅₈O₅

Color and Shape: Solid

Molecular weight: 570.84

Ref: TM-T201276