CAS 35337-98-5

Monocrotaline, N-oxide

Description:

Monocrotaline N-oxide is a chemical compound derived from monocrotaline, which is an alkaloid found in plants of the Crotalaria genus. It is characterized by its molecular structure, which includes a pyrrolidine ring and an N-oxide functional group. This compound is known for its biological activity, particularly its potential toxicity and effects on the cardiovascular system. Monocrotaline N-oxide has been studied for its role in inducing pulmonary hypertension and other pathological conditions in various animal models. Its mechanism of action is thought to involve the formation of reactive metabolites that can cause cellular damage and inflammation. Additionally, it is important to handle this compound with care due to its toxicological properties. In terms of physical properties, monocrotaline N-oxide is typically a solid at room temperature, with specific solubility characteristics that may vary depending on the solvent used. Overall, this compound serves as a significant subject of research in toxicology and pharmacology, particularly concerning its effects on human health and environmental safety.

Formula: C₁₆H₂₃NO₇

InChI: InChI=1S/C16H23NO7/c1-9-13(18)24-11-5-7-17(22)6-4-10(12(11)17)8-23-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3

InChI key: InChIKey=LHVAZUAALQTANZ-UHFFFAOYSA-N

SMILES: O=N12C3C(CC1)OC(=O)C(C)C(C)(O)C(C)(O)C(=O)OCC3=CC2

Synonyms:

• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, 4-oxide, (13α,14α)-
• Monocrotaline oxide
• 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, 11-oxide, (3R,4S,5S,13aR,13bR)-
• Monocrotaline, N-oxide

(13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide

CAS: 35337-98-5

Formula: C₁₆H₂₃NO₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 341.3563

Ref: IN-DA00C99X

Monocrotaline N-Oxide

CAS: 35337-98-5

Monocrotaline N-Oxide

Purity: ≥98%

Molecular weight: 341.36g/mol

Ref: 54-BUP00331

Monocrotaline N-Oxide

CAS: 35337-98-5

Formula: C₁₆H₂₃NO₇

Molecular weight: 341.36

Ref: 7W-GY6128

Monocrotaline N-Oxide

CAS: 35337-98-5

Formula: C₁₆H₂₃NO₇

Purity: 95%~99%

Molecular weight: 341.36

Ref: BP-BP4091

Monocrotaline N-Oxide

CAS: 35337-98-5

Formula: C₁₆H₂₃NO₇

Color and Shape: White To Off-White Solid

Molecular weight: 341.36

Ref: 4Z-M-167004

Monocrotaline N-Oxide

CAS: 35337-98-5

Monocrotaline N-Oxide is a monocrotaline metabolite.

Formula: C₁₆H₂₃NO₇

Purity: 98.31%

Color and Shape: Solid

Molecular weight: 341.36

Ref: TM-T19433

Monocrotaline N-Oxide-d3

CAS: 35337-98-5

Formula: C₁₆H₂₀D₃NO₇

Molecular weight: 344.38

Ref: 4Z-M-167005

Monocrotaline n-oxide

CAS: 35337-98-5

Natural alkaloid

Formula: C₁₆H₂₃NO₇

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 341.36

Ref: 5G-82629

Monocrotaline N-Oxide

CAS: 35337-98-5

Applications Monocrotaline N-oxide is a pyrrolizidine alkaloid that is hepatoxic to livestock and carcinogenic to rats. Monocrotaline N-oxide is extracted from Crotalaria grahamiana, a legume-bearing, perennial shrub that grows in South India, and in some parts of Kenya.
References Bünemann, E., et al.: Plant and Soil, 264, 195 (2004); Davenport, J. & Conner, W.: J. Insect Sci., 3, No pp. given (2003); Wang, J., et al.: Asian J. Trad. Med., 4, 41 (2009)

Formula: C₁₆H₂₃NO₇

Purity: >80%

Color and Shape: Neat

Molecular weight: 341.36

Ref: TR-M526005

Monocrotaline N-Oxide-D4

Controlled Product

CAS: 35337-98-5

Applications Monocrotaline N-oxide-D4 is a labelled analogue of Monocrotaline N-oxide (M526005). Monocrotaline N-oxide is a pyrrolizidine alkaloid that is hepatoxic to livestock and carcinogenic to rats. Monocrotaline N-oxide is extracted from Crotalaria grahamiana, a legume-bearing, perennial shrub that grows in South India, and in some parts of Kenya.
References Bünemann, E., et al.: Plant and Soil, 264, 195 (2004); Davenport, J. & Conner, W.: J. Insect Sci., 3, No pp. given (2003); Wang, J., et al.: Asian J. Trad. Med., 4, 41 (2009)

Formula: C₁₆D₄H₁₉NO₇

Color and Shape: Neat

Molecular weight: 345.381

Ref: TR-M526007

Monocrotaline N-oxide

CAS: 35337-98-5

Monocrotaline N-oxide is a metabolite of monocrotaline. Monocrotaline is an alkaloid that is found in plants and has been used as a rodenticide and insecticide. The LC-MS/MS method was developed for the analysis of monocrotaline N-oxide. The method is selective, sensitive, and accurate. It has been shown to be effective in the detection of retrorsine and retronecine esters in rat liver microsomes. Monocrotaline N-oxide has been shown to have skin cancer promoting effects in rats when applied to skin at doses of 400 ppm or greater. This metabolite also has an effect on uptake by human liver cells, which may be due to its ability to form a matrix with proteins present in the cell membrane.

Formula: C₁₆H₂₃NO₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 341.36 g/mol

Ref: 3D-FM161610

Monocrotaline N-Oxide

CAS: 35337-98-5

Formula: C₁₆H₂₃NO₇

Molecular weight: 341.4

Ref: ST-EA-CP-M160001