CAS 35410-28-7

(11β)-11,17-Dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione

Description:

The chemical substance known as (11β)-11,17-Dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione, with the CAS number 35410-28-7, is a synthetic glucocorticoid. It is characterized by its steroidal structure, which includes a pregnane backbone, and features hydroxyl groups at the 11 and 17 positions, contributing to its biological activity. The presence of a methylsulfonyl group at the 21 position enhances its solubility and may influence its pharmacokinetic properties. This compound exhibits anti-inflammatory and immunosuppressive effects, making it useful in various therapeutic applications, particularly in treating conditions such as asthma, allergies, and autoimmune disorders. Its mechanism of action typically involves the modulation of gene expression through interaction with glucocorticoid receptors, leading to the regulation of inflammatory mediators. As with many glucocorticoids, careful consideration of dosage and potential side effects is essential in clinical use. Overall, this compound exemplifies the structural complexity and functional versatility of synthetic corticosteroids in medicinal chemistry.

Formula: C₂₂H₃₀O₇S

InChI: InChI=1S/C22H30O7S/c1-20-8-6-14(23)10-13(20)4-5-15-16-7-9-22(26,18(25)12-29-30(3,27)28)21(16,2)11-17(24)19(15)20/h6,8,10,15-17,19,24,26H,4-5,7,9,11-12H2,1-3H3/t15-,16-,17-,19+,20-,21-,22-/m0/s1

InChI key: InChIKey=TZEYKLAAPSZABE-CWNVBEKCSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])(CC[C@@]2(C(COS(C)(=O)=O)=O)O)[H]

Synonyms:

• (11β)-11,17-Dihydroxy-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione
• 252-549-2
• Prednisolone 21-methanesulfonate
• Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-[(methylsulfonyl)oxy]-, (11β)-
• Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-, 21-methanesulfonate
• [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] methanesulfonate

Prednisolone 21-Methanesulfonate

Controlled Product

CAS: 35410-28-7

Formula: C₂₂H₃₀O₇S

Color and Shape: Neat

Molecular weight: 438.534

Ref: TR-P703765

Prednisolone 21-Mesylate

CAS: 35410-28-7

Formula: C₂₂H₃₀O₇S

Molecular weight: 438.54

Ref: ST-EA-CP-P20060