CAS 3543-75-7

Bendamustine hydrochloride

Description:

Bendamustine hydrochloride is a synthetic alkylating agent used primarily in oncology for the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. It is classified as a nitrogen mustard derivative and exhibits both alkylating and antimetabolite properties, which contribute to its effectiveness in disrupting DNA synthesis and cell division in rapidly dividing cancer cells. The compound is typically administered intravenously and is known for its relatively favorable side effect profile compared to other chemotherapeutic agents. Bendamustine hydrochloride is soluble in water and exhibits stability under acidic conditions, making it suitable for formulation in injectable solutions. Its mechanism of action involves the formation of DNA cross-links, leading to apoptosis in malignant cells. Additionally, it has been noted for its immunomodulatory effects, which may enhance the immune response against tumors. As with all chemotherapeutic agents, careful monitoring for adverse effects and patient response is essential during treatment.

Formula: C₁₆H₂₁Cl₂N₃O₂·ClH

InChI: InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H

InChI key: InChIKey=ZHSKUOZOLHMKEA-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(N(CCCl)CCCl)=CC2)N=C1CCCC(O)=O.Cl

Synonyms:

• 1-Methyl-5-Bis(2-Chloroethyl)Amino-2-Benzimidazolinebutryric Acid Hydrochloride
• 1-Methyl-5-Bis(2-Chloroethyl)Amino-2-Benzimidazolinebutryricacihydrochlor
• 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, hydrochloride (1:1)
• 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, monohydrochloride
• 2-Benzimidazolebutyric acid, 5-[bis(2-chloroethyl)amino]-1-methyl-, monohydrochloride
• 4-[5-[Bis(2-Chloroethyl)Amino]-1-Methylbenzimidazol-2-Yl]Butanoic Acid Hydrochloride
• 4-[5-[Bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butyric acid hydrochloride
• 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoic acid hydrochloride (1:1)
• Bendamustin HCL
• Bendamustin Hydrochloride
• Bendamustine Hcl
• Bendit
• Cytostasan
• CytostasanHCl
• Gamma(1-Methyl-5-Bis(Beta-Chloraethyl)Aminobenzimidazoyl-2)Buttersaeurehydro
• Imet 3393
• Purplz
• Ribomustin
• Sdx 105
• Treanda

Bendamustine Hydrochloride

CAS: 3543-75-7

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₁₆H₂₁Cl₂N₃O₂·HCl

Color and Shape: White Solid

Molecular weight: 393.07776

Ref: 45-1065221

Bendamustine hydrochloride

CAS: 3543-75-7

Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.

Formula: C₁₆H₂₁Cl₂N₃O₂·HCl

Purity: 97.71%

Color and Shape: Solid

Molecular weight: 394.72

Ref: TM-T0095

Bendamustine hydrochloride hydrate

CAS: 3543-75-7

Formula: C₁₆H₂₂Cl₃N₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 394.7238

Ref: IN-DA0039BQ

Bendamustine hydrochloride

CAS: 3543-75-7

Bendamustine hydrochloride

Purity: 99%

Molecular weight: 394.72g/mol

Ref: 54-OR1012316

Bendamustine-d4 HCl

CAS: 3543-75-7

Formula: C₁₆H₁₇D₄Cl₂N₃O₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 362.29 36.46

Ref: 4Z-B-436

Bendamustine hydrochloride

CAS: 3543-75-7

Bendamustine hydrochloride

Purity: ≥95%

Molecular weight: 394.72g/mol

Ref: 54-BUP15045

Bendamustine HCl

CAS: 3543-75-7

Formula: C₁₆H₂₁Cl₂N₃O₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 358.27 36.46

Ref: 4Z-B-435

Bendamustine Hydrochloride

Controlled Product

CAS: 3543-75-7

Formula: C₁₆H₂₁Cl₂N₃O₂·ClH

Color and Shape: Neat

Molecular weight: 394.72

Ref: 86-MM0154.00

Bendamustine hydrochloride

CAS: 3543-75-7

Formula: C₁₆H₂₁Cl₂N₃O₂·HCl·xH₂O

Purity: ≥ 98.0%

Color and Shape: White to yellow crystalline powder

Molecular weight: 394.72 (anhydrous)

Ref: 7W-GP6515

Bendamustine Hydrochloride

CAS: 3543-75-7

Formula: C₁₆H₂₀₂N₃O₂HCl

Molecular weight: 358.3 : 36.5

Ref: ST-EA-CP-B7013

Bendamustine Hydrochloride

Controlled Product

CAS: 3543-75-7

Applications Bendamustine Hydrochloride is used as an anticancer drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bremer, K., et al.: Tumordiagn. Ther., 17, 1 (1996); Barman Balfour, J.A., et al.: Drugs, 61, 631 (2001);

Formula: C₁₆H₂₁Cl₂N₃O₂·HCl

Color and Shape: White To Beige

Molecular weight: 394.72

Ref: TR-B132500

Bendamustine-d6 (major) Hydrochloride

Controlled Product

CAS: 3543-75-7

Applications Labelled Bendamustine (B132502). Bendamustine is an antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bremer, K., et al.: Tumordiagn. Ther., 17, 1 (1996), Barman Balfour, J.A., et al.: Drugs, 61, 631 (2001),

Formula: C₁₆H₁₆D₆Cl₃N₃O₂

Color and Shape: Neat

Molecular weight: 400.76

Ref: TR-B132502

Bendamustine HCl - Bio-X ™

CAS: 3543-75-7

Bendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite properties. An alkylating group, a benzimidazole ring that may function as a purine analog, and a butyric acid side chain are the three active moieties found in bendamustine. Through its function as an alkylating agent, Bendamustine causes intra and inter-strand crosslinks between DNA bases resulting in DNA, RNA synthesis inhibition and cell death.

Formula: C₁₆H₂₁Cl₂N₃O₂•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 394.72 g/mol

Ref: 3D-BB164239

Bendamustine hydrochloride

CAS: 3543-75-7

DNA alkylator; purine analog

Formula: C₁₆H₂₂Cl₃N₃O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 394.72 g/mol

Ref: 3D-FB18163

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride

CAS: 3543-75-7

Formula: C₁₆H₂₂Cl₃N₃O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 394.72

Ref: 10-F223196