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CAS 3544-94-3

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Chloramphenicol succinate

Description:
Chloramphenicol succinate is a derivative of chloramphenicol, an antibiotic that is effective against a wide range of bacteria. This compound is characterized by its esterification with succinic acid, which enhances its solubility and stability compared to its parent compound. Chloramphenicol succinate is typically a white to off-white crystalline powder, and it is soluble in water, making it suitable for various pharmaceutical formulations. The compound retains the antibacterial properties of chloramphenicol, which works by inhibiting bacterial protein synthesis. It is primarily used in the treatment of serious infections caused by susceptible organisms, particularly in cases where other antibiotics may not be effective. Due to its potential side effects, including bone marrow suppression, its use is often limited to specific clinical situations. Additionally, chloramphenicol succinate is subject to regulatory scrutiny, and its use is monitored to prevent adverse reactions. Overall, this compound exemplifies the modifications made to enhance the pharmacological properties of existing antibiotics.
Formula:C15H16Cl2N2O8
InChI:InChI=1S/C15H16Cl2N2O8/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21)/t10-,13-/m1/s1
InChI key:InChIKey=LIRCDOVJWUGTMW-ZWNOBZJWSA-N
SMILES:[C@@H]([C@H](O)C1=CC=C(N(=O)=O)C=C1)(NC(C(Cl)Cl)=O)COC(CCC(O)=O)=O
Synonyms:
  • (2-((Dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) hydrogen (R-(R*,R*))-succinate
  • 4-{2-[(Dichloroacetyl)Amino]-3-Hydroxy-3-(4-Nitrophenyl)Propoxy}-4-Oxobutanoic Acid
  • 4-{[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl]oxy}-4-oxobutanoic acid
  • Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, α-(hydrogen succinate), <span class="text-smallcaps">D</span>-(-)-threo-
  • Brn 3228488
  • Butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester
  • Butanedioic acid, mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, [R-(R*,R*)]-
  • Chloramphenicol 3-monosuccinate
  • Chloramphenicol acid succinate
  • Chloramphenicol hemisuccinate
  • See more synonyms
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