CAS 355400-87-2

5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

Description:

5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid, with CAS number 355400-87-2, is a synthetic organic compound characterized by its complex structure, which includes a thiazolidine ring, a thioxo group, and multiple functional groups such as bromine, ethoxy, and hydroxy substituents. This compound exhibits potential biological activity, often investigated for its pharmacological properties, including antimicrobial and anti-inflammatory effects. The presence of bromine atoms enhances its reactivity and may influence its interaction with biological targets. The thiazolidine framework contributes to its stability and solubility in various solvents, making it suitable for further chemical modifications. Additionally, the compound's unique structural features may allow for specific interactions with enzymes or receptors, which is of interest in medicinal chemistry. Overall, this compound represents a class of thiazolidine derivatives that are valuable in drug discovery and development, particularly in the search for new therapeutic agents.

Formula: C₁₄H₁₁Br₂NO₅S₂

Synonyms:

• 5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
• RU7
• RU7 >=98% (HPLC)
• 3-Thiazolidineacetic acid, 5-[(2,3-dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-
• [(5E)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid

Topoisomerase I/II inhibitor 8

CAS: 355400-87-2

TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.

Formula: C₁₄H₁₁Br₂NO₅S₂

Color and Shape: Solid

Molecular weight: 497.179

Ref: TM-T204994