CAS 356068-94-5

Toceranib

Description:

Toceranib, with the CAS number 356068-94-5, is a small molecule tyrosine kinase inhibitor primarily used in veterinary medicine, particularly for the treatment of certain types of cancer in dogs. It is known for its ability to inhibit multiple receptor tyrosine kinases, including those involved in tumor growth and angiogenesis, making it effective against tumors such as mast cell tumors. Toceranib is administered orally and is characterized by its moderate solubility in water and its stability under normal conditions. The compound has a specific chemical structure that allows it to interact with the ATP-binding site of kinases, thereby blocking their activity. Its pharmacokinetics include absorption, distribution, metabolism, and excretion, which are crucial for determining dosing regimens. Side effects may include gastrointestinal disturbances and potential impacts on blood cell counts, necessitating monitoring during treatment. Overall, Toceranib represents an important therapeutic option in veterinary oncology, showcasing the application of targeted therapies in animal health.

Formula: C₂₂H₂₅FN₄O₂

InChI: InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-

InChI key: InChIKey=SRSGVKWWVXWSJT-ATVHPVEESA-N

SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3

Synonyms:

• 1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-
• 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-(pyrrolidin-1-yl)ethyl)amide
• 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
• Palladia
• Pha 291639
• Su-11654
• Toceranib

Toceranib

CAS: 356068-94-5

Formula: C₂₂H₂₅FN₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 396.4579

Ref: IN-DA00C6I2

Toceranib

CAS: 356068-94-5

Toceranib

Purity: 98%

Molecular weight: 396.46g/mol

Ref: 54-PC109155

Toceranib

CAS: 356068-94-5

Toceranib

Purity: ≥95%

Molecular weight: 396.46g/mol

Ref: 54-BUP11366

Toceranib

CAS: 356068-94-5

Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.

Formula: C₂₂H₂₅FN₄O₂

Purity: 97.62%

Color and Shape: Solid

Molecular weight: 396.46

Ref: TM-T13178

(Z)-5-(5-FLUORO-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-N-[2-(1-PYRROLIDINYL)ETHYL]-1H-PYRROLE-3-CARBOXAMIDE

CAS: 356068-94-5

Formula: C₂₂H₂₅FN₄O₂

Purity: 98%

Molecular weight: 396.466

Ref: 10-F387052

Toceranib

CAS: 356068-94-5

Inhibitor of receptor tyrosine kinases

Formula: C₂₂H₂₅FN₄O₂

Purity: Min. 95%

Molecular weight: 396.46 g/mol

Ref: 3D-FT44529