CymitQuimica logo

CAS 356068-94-5

:

Toceranib

Description:
Toceranib, with the CAS number 356068-94-5, is a small molecule tyrosine kinase inhibitor primarily used in veterinary medicine, particularly for the treatment of certain types of cancer in dogs. It is known for its ability to inhibit multiple receptor tyrosine kinases, including those involved in tumor growth and angiogenesis, making it effective against tumors such as mast cell tumors. Toceranib is administered orally and is characterized by its moderate solubility in water and its stability under normal conditions. The compound has a specific chemical structure that allows it to interact with the ATP-binding site of kinases, thereby blocking their activity. Its pharmacokinetics include absorption, distribution, metabolism, and excretion, which are crucial for determining dosing regimens. Side effects may include gastrointestinal disturbances and potential impacts on blood cell counts, necessitating monitoring during treatment. Overall, Toceranib represents an important therapeutic option in veterinary oncology, showcasing the application of targeted therapies in animal health.
Formula:C22H25FN4O2
InChI:InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
InChI key:InChIKey=SRSGVKWWVXWSJT-ATVHPVEESA-N
SMILES:C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3
Synonyms:
  • 1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-
  • 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-(pyrrolidin-1-yl)ethyl)amide
  • 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
  • Palladia
  • Pha 291639
  • Su-11654
  • Toceranib
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 6 products.