CAS 356068-99-0

Sunitinib N-Oxide ((Z)-N,N-diethyl-2-(5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamido)ethan-1-amine oxide)

CAS: 356068-99-0

Lactams, nesoi

Formula: C₂₂H₂₇FN₄O₃

Color and Shape: Yellow Orange Solid

Molecular weight: 414.20672

Ref: 45-1A05050

Sunitinib N-Oxide

CAS: 356068-99-0

Formula: C₂₂H₂₇FN₄O₃

Color and Shape: Orange Solid

Molecular weight: 414.48

Ref: 4Z-S-415

Sunitinib N-Oxide

CAS: 356068-99-0

Color and Shape: Neat

Ref: 86-MM3568.05

Sunitinib N-Oxide

CAS: 356068-99-0

Formula: C₂₂H₂₇FN₄O₃

Molecular weight: 414.48

Ref: ST-EA-CP-S42009

Sunitinib N-Oxide

CAS: 356068-99-0

Stability Hygroscopic
Applications Sunitinib N-Oxide, is a derivative of Sunitinib (S820000), a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK), used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor. It is a COVID19-related research product.
References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),

Formula: C₂₂H₂₇FN₄O₃

Color and Shape: Neat

Molecular weight: 414.47

Ref: TR-S820005

Sunitinib N-Oxide-d10

Controlled Product

CAS: 356068-99-0

Formula: C₂₂D₁₀H₁₇FN₄O₃

Color and Shape: Neat

Molecular weight: 424.535

Ref: TR-S820007

Sunitinib N-oxide

CAS: 356068-99-0

Sunitinib N-oxide is the active form of sunitinib, a drug that is used to treat cancer. Sunitinib N-oxide is a photolabile n-oxide and can be converted to sunitinib by exposure to light. This conversion process can be used as an analytical technique for determining the concentration of the drug in blood or tissue samples. Sunitinib N-oxide has been shown to reduce tumor growth in mouse models and also inhibits angiogenesis and tumor metastasis. The drug has also been shown to have anti-inflammatory effects, which may be due to its inhibition of prostaglandin synthesis.

Formula: C₂₂H₂₇FN₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 414.47 g/mol

Ref: 3D-FS146111