CAS 35654-56-9

6,7-Dimethoxy-4-chloroquinoline

Description:

6,7-Dimethoxy-4-chloroquinoline is a chemical compound characterized by its quinoline backbone, which is a bicyclic structure containing a benzene ring fused to a pyridine ring. This compound features two methoxy groups (-OCH3) at the 6 and 7 positions and a chlorine atom at the 4 position of the quinoline ring, contributing to its unique chemical properties. It is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. The presence of the methoxy groups can influence its reactivity and polarity, while the chlorine substituent may enhance its biological activity. Compounds of this type are often studied for their potential pharmacological applications, including antimicrobial and antitumor properties. Additionally, the structural modifications provided by the methoxy and chloro groups can affect the compound's interaction with biological targets, making it of interest in medicinal chemistry. As with many quinoline derivatives, safety and handling precautions should be observed due to potential toxicity.

Formula: C₁₁H₁₀ClNO₂

InChI: InChI=1/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3

SMILES: COc1cc2c(ccnc2cc1OC)Cl

Synonyms:

• 4-Chloro-6,7-dimethoxyquinoline
• 4-Chloro-6,7-dimethoxyquioline
• 4-chloro-6,7-dimethoxy-Quinoline

4-Chloro-6,7-dimethoxyquinoline

CAS: 35654-56-9

Formula: C₁₁H₁₀ClNO₂

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 223.66

Ref: 3B-C2938

4-Chloro-6,7-dimethoxyquinoline

CAS: 35654-56-9

Formula: C₁₁H₁₀ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 223.6556

Ref: IN-DA003L5R

4-Chloro-6,7-dimethoxyquinoline

CAS: 35654-56-9

4-Chloro-6,7-dimethoxyquinoline

Purity: 99%

Molecular weight: 223.66g/mol

Ref: 54-OR301095

Cabozantinib Impurity 4

CAS: 35654-56-9

Formula: C₁₁H₁₀ClNO₂

Molecular weight: 223.66

Ref: 4Z-C-284009

Cabozantinib Impurity 3

CAS: 35654-56-9

Formula: C₁₁H₁₀ClNO₂

Molecular weight: 223.66

Ref: ST-EA-CP-C46010

4-Chloro-6,7-dimethoxy-quinoline

CAS: 35654-56-9

Formula: C₁₁H₁₀ClNO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 223.66

Ref: 10-F040711

4-Chloro-6,7-dimethoxyquinoline

CAS: 35654-56-9

Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.
References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);

Formula: C₁₁H₁₀ClNO₂

Color and Shape: Neat

Molecular weight: 223.66

Ref: TR-C365930

4-Chloro-6,7-dimethoxyquinoline

CAS: 35654-56-9

4-Chloro-6,7-dimethoxyquinoline (4C6DMQ) is a potent inhibitor of the growth of prostate cancer cells. 4C6DMQ is an analog of chloropropyl chloride, which inhibits the growth of epidermal growth factor receptor (EGFR). The binding site for 4C6DMQ on EGFR is the same as that for chloropropyl chloride. 4C6DMQ inhibits EGFR by preventing the activation of downstream signaling cascades, leading to a decrease in cell proliferation and tumor size. The IC50 values for 4C6DMQ are approximately 10 times higher than those for chloropropyl chloride. This drug has been shown to be more potent than other inhibitors of EGFR such as erlotinib and gefitinib.

Formula: C₁₁H₁₀ClNO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 223.66 g/mol

Ref: 3D-FC42168