CAS 356568-70-2

3-Amino-5-[4-(phenylmethyl)phenyl]thieno[2,3-d]pyrimidin-4(3H)-one

Description:

3-Amino-5-[4-(phenylmethyl)phenyl]thieno[2,3-d]pyrimidin-4(3H)-one is a heterocyclic compound characterized by its thieno[2,3-d]pyrimidine core, which incorporates both sulfur and nitrogen atoms in its structure. This compound features an amino group at the 3-position and a phenylmethyl substituent at the 5-position, contributing to its potential biological activity. The presence of the thieno and pyrimidine rings suggests that it may exhibit interesting pharmacological properties, possibly acting as an inhibitor or modulator in various biochemical pathways. The compound's molecular structure indicates it may have lipophilic characteristics due to the phenyl groups, which can influence its solubility and permeability in biological systems. Additionally, the specific arrangement of functional groups may allow for interactions with specific receptors or enzymes, making it a candidate for further research in medicinal chemistry. Overall, this compound's unique structure and functional groups position it as a potentially valuable substance in drug discovery and development.

Formula: C₁₉H₁₅N₃OS

InChI: InChI=1S/C19H15N3OS/c20-22-12-21-18-17(19(22)23)16(11-24-18)15-8-6-14(7-9-15)10-13-4-2-1-3-5-13/h1-9,11-12H,10,20H2

InChI key: InChIKey=OCBXPCSXEQQADU-UHFFFAOYSA-N

SMILES: O=C1C=2C(=CSC2N=CN1N)C3=CC=C(CC4=CC=CC=C4)C=C3

Synonyms:

• Barbadin
• 3-Amino-5-[4-(phenylmethyl)phenyl]thieno[2,3-d]pyrimidin-4(3H)-one
• Thieno[2,3-d]pyrimidin-4(3H)-one, 3-amino-5-[4-(phenylmethyl)phenyl]-
• 3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4-one

Barbadin

CAS: 356568-70-2

Barbadin

Purity: ≥98%

Molecular weight: 333.41g/mol

Ref: 54-BUP21126

Barbadin

CAS: 356568-70-2

Barbadin is an inhibitor of β-arrestin/β2-adaptin interaction.Barbadin enhances the effects of lorcaserin on weight loss and can be used to study obesity.

Formula: C₁₉H₁₅N₃OS

Purity: 98.93% - 99.10%

Color and Shape: Solid

Molecular weight: 333.41

Ref: TM-T14498

Barbadin

Controlled Product

CAS: 356568-70-2

Applications Barbadin is a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.
References Beautrait, A., et al.: Nat Commun. 8, 15054 (2017)

Formula: C₁₉H₁₅N₃OS

Color and Shape: Neat

Molecular weight: 333.41

Ref: TR-B118250