Description:Fmoc-Gly-Gly-OH, also known as Fmoc-diglycine, is a dipeptide derivative characterized by the presence of two glycine residues linked by a peptide bond, with a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group attached to the amino terminus. This compound is commonly used in peptide synthesis as a building block due to its stability and ease of handling. The Fmoc group serves as a protective moiety that can be removed under basic conditions, allowing for the selective deprotection of the amino group during peptide assembly. Fmoc-Gly-Gly-OH is typically white to off-white in appearance and is soluble in common organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but less soluble in water. Its molecular structure contributes to its role in various biochemical applications, including drug development and the study of protein interactions. As with many peptides, care should be taken when handling this substance, as it may pose health risks if ingested or inhaled.
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