CAS 357-08-4

Naloxone hydrochloride

Description:

Naloxone hydrochloride is an opioid antagonist primarily used in emergency medicine to counteract opioid overdose. It is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous, intramuscular, or subcutaneous administration. The chemical formula of naloxone hydrochloride is C19H21NO4•HCl, and it has a molecular weight of approximately 343.84 g/mol. This compound works by competitively binding to opioid receptors in the central nervous system, effectively reversing the effects of opioids, such as respiratory depression and sedation. Naloxone has a rapid onset of action, typically within minutes, and its effects can last from 30 to 90 minutes, depending on the dose and route of administration. It is important to note that naloxone is not effective against non-opioid drug overdoses and may precipitate withdrawal symptoms in individuals dependent on opioids. Naloxone hydrochloride is a critical tool in public health for preventing opioid-related fatalities and is often available in various formulations, including auto-injectors and nasal sprays.

Formula: C₁₉H₂₂ClNO₄

InChI: InChI=1/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

InChI key: InChIKey=RGPDIGOSVORSAK-STHHAXOLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H].Cl

Synonyms:

• (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride
• (5Alpha)-3,14-Dihydroxy-17-Prop-2-En-1-Yl-4,5-Epoxymorphinan-6-One Hydrochloride
• En 1530
• En 15304
• Morphinan-6-one, 17-allyl-4,5α-epoxy-3,14-dihydroxy-, hydrochloride
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, hydrochloride (1:1), (5α)-
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5α)-
• N-Allyldihydro-14-hydroxynormorphinone hydrochloride
• Nalone
• Nalonee
• Naloxone HCl
• Narcan
• Narcanti
• Narcoxone
• Nih 7890
• Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride
• l-Naloxone hydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride
• en1530
• (5alpha)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
• 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride
• (5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE
• l-n-allyl-14-hydroxynordihydromorphinonehydrochloride
• morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,hydrochloride,(5-a
• NALOXONE HYDROCHLORIDE CRYSTALLINE
• NALOXONE HYDROCHLORIDE OPIOID ANTAGONIST
• nih7890
• (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one Hydrochloride
• NALOXONE HYDROCHLORIDE

Naloxone hydrochloride, 98%

CAS: 357-08-4

Naloxone hydrochloride, 357-08-4, is a salt form of naloxone, a specific opioid antagonist which competitively binds to opioid receptors in the central nervous system. Learn more.

Formula: C₁₉H₂₂ClNO₄

Purity: 98%

Color and Shape: White to off-white, Crystals or powder or crystalline powder

Molecular weight: 363.84

Ref: 02-J60013

Naloxone hydrochloride

CAS: 357-08-4

Naloxone hydrochloride

Formula: C₁₉H₂₁NO₄HCl

Purity: 90.6%

Color and Shape: White To Off-White

Molecular weight: 363.12374

Ref: 47-548

Naloxone HCl

CAS: 357-08-4

Formula: C₁₉H₂₁NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 327.38 36.46

Ref: 4Z-N-211

Naloxone Hydrochloride

CAS: 357-08-4

Formula: C₁₉H₂₁NO₄HCl

Molecular weight: 327.4 : 36.46

Ref: ST-EA-CP-N37001

Naloxone Hydrochloride

Controlled Product

CAS: 357-08-4

Stability Hygroscopic
Applications Naloxone Hydrochloride is a specific opioid antagonist. Narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

Formula: C₁₉H₂₁NO₄·ClH

Color and Shape: Neat

Molecular weight: 363.84

Ref: TR-N285000

Naloxone hydrochloride

Controlled Product

CAS: 357-08-4

Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.

Formula: C₁₉H₂₁NO₄•HCl

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 363.84 g/mol

Ref: 3D-FN26128