CAS 357-57-3

Brucine

Description:

Brucine is an alkaloid derived from the seeds of the Strychnos nux-vomica tree, belonging to the Loganiaceae family. It is a white crystalline powder that is sparingly soluble in water but more soluble in organic solvents such as alcohol and chloroform. Brucine has a bitter taste and is structurally related to strychnine, sharing some pharmacological properties, although it is less toxic. The compound exhibits a variety of biological activities, including potential stimulant effects on the central nervous system. It has been studied for its use in various applications, including as a reagent in analytical chemistry and in the synthesis of other chemical compounds. However, due to its toxicity and potential for misuse, brucine is regulated in many countries. Safety precautions are essential when handling this substance, as it can pose health risks if ingested or improperly managed. Overall, brucine is a significant compound in both natural product chemistry and pharmacology, warranting careful study and consideration.

Formula: C₂₃H₂₆N₂O₄

InChI: InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1

InChI key: InChIKey=RRKTZKIUPZVBMF-IBTVXLQLSA-N

SMILES: O=C1N2[C@@]3([C@]4(C=5C2=CC(OC)=C(OC)C5)[C@]6([N@@](CC4)CC=7[C@@]([C@]3([C@](C1)(OCC7)[H])[H])(C6)[H])[H])[H]

Synonyms:

• (8Xi,12Xi)-2,3-Dimethoxystrychnidin-10-One
• 10,11-Dimethoxystrychnine
• 2,3-Dimethoxystrychnidin-10-One
• 2,3-Dimethoxystrychnine
• 2,3-Dimethylstrychnine
• 357-57-3
• 4,6-Methano-6H,14H-indolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline, strychnidin-10-one deriv.
• Brucin
• Brucina
• Brucine Alkaloid
• Dimethoxystrychnine
• Strychnidin-10-one, 2,3-dimethoxy
• l-Brucine

Brucine Anhydrous

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 394.47

Ref: 3B-B0946

Brucine

CAS: 357-57-3

Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects. This Thermo Scientific Chemicals brand product

Formula: C₂₃H₂₆N₂O₄

Molecular weight: 394.47

Ref: 02-J61178

BRUCINE CRS

CAS: 357-57-3

BRUCINE CRS

Formula: C₂₃H₂₆N₂O₄

Color and Shape: Colourless.

Molecular weight: 394.4635

Ref: 41-Y0001196

Brucine

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 394.47

Ref: 7W-GE5423

Brucine

CAS: 357-57-3

Color and Shape: Neat

Ref: 61-FOR1714.00

Brucine Hydrate

CAS: 145428-94-0, 1638332-73-6, 357-57-3

Formula: C₂₃H₂₆N₂O₄·xH₂O

Purity: >99.0%(T)

Color and Shape: White powder to crystal

Molecular weight: 394.47 (as Anhydrous)

Ref: 3B-B0670

Brucine

Controlled Product

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Color and Shape: Neat

Molecular weight: 394.46

Ref: 86-MM1714.00

Brucine

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Molecular weight: 394.47

Ref: 4Z-S-202002

Brucine

CAS: 357-57-3

Natural alkaloid

Formula: C₂₃H₂₆N₂O₄

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 394.47

Ref: 5G-89586

Brucine

CAS: 357-57-3

Brucine is the 10, 11-dimethoxy derivative of Strychnine; both substances are found in the seeds of Strychnos nux-vomica, the strychnine tree, which is widespread in southern Asia. These Indole-Alkaloids are mainly known for their poisonous properties and they are responsible for the intense bitter taste of the plant extracts. Brucine’s toxicity however is lower compared to the one of Strychnine. Interestingly, some attempts of using Brucine for asymmetric decarboxylations have been reported by Marckwald as early as in 1904. In this context, Brucine can be considered an ancestral organocatalyst.

Formula: C₂₃H₂₆N₂O₄

Purity: Min. 98.0 Area-%

Molecular weight: 394.46 g/mol

Ref: 3D-Q-100426

Brucine, anhydrous

CAS: 357-57-3

Alkaloid with anti-tumoral activity

Formula: C₂₃H₂₆N₂O₄

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 394.46 g/mol

Ref: 3D-FB19344

Brucine, Anhydrous

Controlled Product

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Color and Shape: Brown

Molecular weight: 394.46

Ref: TR-B689325

Brucine Anhydrous Reagent Grade, 98%

CAS: 357-57-3

Formula: C₂₃H₂₆N₂O₄

Purity: min.98%

Color and Shape: White to off white, Crystaline powder /Crystals/Chunks

Molecular weight: 394.46

Ref: SR-27691