CAS 357-70-0

(-)-Galantamine

Description:

(-)-Galantamine is a naturally occurring alkaloid primarily derived from the bulbs and flowers of certain plants, such as snowdrop and daffodil. It is classified as a reversible inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the breakdown of the neurotransmitter acetylcholine. This characteristic makes (-)-Galantamine significant in the treatment of Alzheimer's disease and other cognitive disorders, as it helps to increase acetylcholine levels in the brain, thereby enhancing cholinergic function. The compound has a molecular formula of C17H21NO3 and features a bicyclic structure that includes a phenolic ring. It is known for its ability to cross the blood-brain barrier, which is essential for its therapeutic effects. Additionally, (-)-Galantamine exhibits various pharmacological properties, including neuroprotective and anti-inflammatory effects. Its stereochemistry is important for its biological activity, with the (-) enantiomer being the active form. The substance is typically administered in oral form and is well-tolerated, although it may have side effects such as nausea or dizziness in some individuals.

Formula: C₁₇H₂₁NO₃

InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

InChI key: InChIKey=ASUTZQLVASHGKV-JDFRZJQESA-N

SMILES: O(C)C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1

Synonyms:

• (-)-Galantamine
• (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
• 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-
• 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-
• 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, [4aS-(4aα,6β,8aR*)]-
• Brn 0093736
• Galantamin
• Galantamina
• Galanthamine
• Galanthamine Hydrochloride (1:1)
• Jilkon
• Lycoremin
• Lycoremine

Galantamine Hydrobromide

CAS: 1953-04-4, 357-70-0

Formula: C₁₇H₂₁NO₃·HBr

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 368.27

Ref: 3B-G0293

Galanthamine

CAS: 357-70-0

Formula: C₁₇H₂₁NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 287.3535

Ref: IN-DA0038S4

(4As,6R,8As)-3-Methoxy-11-Methyl-5,6,9,10,11,12-Hexahydro-4Ah-Benzo[2,3]Benzofuro[4,3-Cd]Azepin-6-Ol

CAS: 357-70-0

(4As,6R,8As)-3-Methoxy-11-Methyl-5,6,9,10,11,12-Hexahydro-4Ah-Benzo[2,3]Benzofuro[4,3-Cd]Azepin-6-Ol

Purity: 98%

Molecular weight: 287.35g/mol

Ref: 54-OR1026224

Galanthamine

CAS: 357-70-0

Galanthamine

Purity: ≥98%

Molecular weight: 287.35g/mol

Ref: 54-BUP14915

Galanthamine

CAS: 357-70-0

Formula: C₁₇H₂₁NO₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 287.36

Ref: 3B-G0632

Galanthamine

CAS: 357-70-0

Formula: C₁₇H₂₁NO₃

Purity: 95%~99%

Molecular weight: 287.359

Ref: BP-BP0606

Galanthamine

CAS: 357-70-0

Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.

Formula: C₁₇H₂₁NO₃

Purity: 98.03% - 99.87%

Color and Shape: Off-White Solid

Molecular weight: 287.35

Ref: TM-T4S1725

Galanthamine

CAS: 357-70-0

Applications A selective acetylcholinesterase inhibitor. Useful for the treatment of Alzheimer's disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991), Maelicke, A., et al.: Drugs Dis Today, 1, 53 (1996), Sauvaltre, T., et al.: J. Med. Chem., 50, 5311 (2007),

Formula: C₁₇H₂₁NO₃

Color and Shape: Neat

Molecular weight: 287.35

Ref: TR-G188501

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol

Controlled Product

CAS: 357-70-0

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol is a natural compound that has been shown to be an effective treatment for oxidative injury. It has a cholinergic activity and is able to cross the blood brain barrier. (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6Hbenzofuro[3a. 3.2ef][2]benzazepin -6--ol was found to have protective effects in an experimental model of Alzheimer's disease where it significantly reduced neuronal death. The compound also has antiinflammatory properties which may

Formula: C₁₇H₂₁NO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 287.35 g/mol

Ref: 3D-FH15703

Galantamine Hydrobromide

CAS: 357-70-0

Color and Shape: Neat

Ref: 61-FOR1256.00