CAS 35711-34-3

Tolmetin sodium

Description:

Tolmetin sodium is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is characterized by its ability to inhibit cyclooxygenase enzymes, which play a crucial role in the synthesis of prostaglandins, thereby reducing pain and inflammation. Tolmetin sodium is typically administered in its salt form, enhancing its solubility and bioavailability. The compound is often utilized in the treatment of conditions such as arthritis and other inflammatory disorders. In terms of physical properties, tolmetin sodium is a white to off-white crystalline powder, which is soluble in water and exhibits a moderate melting point. Its pharmacokinetics involve rapid absorption, with peak plasma concentrations occurring within a few hours post-administration. Common side effects may include gastrointestinal discomfort, dizziness, and potential allergic reactions. As with other NSAIDs, caution is advised in patients with a history of cardiovascular or gastrointestinal issues. Overall, tolmetin sodium is an effective therapeutic agent in managing pain and inflammation, with a well-established safety profile when used appropriately.

Formula: C₁₅H₁₅NO₃·Na

InChI: InChI=1S/C15H15NO3.Na/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;/h3-8H,9H2,1-2H3,(H,17,18);

InChI key: InChIKey=OWZONIAJECYIHO-UHFFFAOYSA-N

SMILES: C(=O)(C=1N(C)C(CC(O)=O)=CC1)C2=CC=C(C)C=C2.[Na]

Synonyms:

• 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt
• 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (1:1)
• 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
• 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, hydrate (1:1:2)
• Sodium 1-methyl-5-p-toluoylpyrrole-2-acetate
• Sodium [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetate dihydrate
• Sodium [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetate hydrate (1:1:2)
• Sodium tolmetin
• Tolectin
• Tolmetin sodium
• Tolmetin sodium anhydrous

Tolmetin sodium

CAS: 35711-34-3

Formula: C₁₅H₁₄NNaO₃

Molecular weight: 279.27

Ref: 7W-GP9668

Tolmetin Sodium Salt

CAS: 35711-34-3

Formula: C₁₅H₁₄NO₃·Na

Color and Shape: White To Off-White Solid

Molecular weight: 256.28 22.99

Ref: 4Z-T-131002

Tolmetin sodium

CAS: 35711-34-3

Tolmetin sodium is an NSAID, orally active COX inhibitor with IC50 of 0.35 μM (COX-1) and 0.82 μM (COX-2).

Formula: C₁₅H₁₄NNaO₃

Color and Shape: Solid

Molecular weight: 279.271

Ref: TM-T60518

Tolmetin Sodium

Controlled Product

CAS: 35711-34-3

Applications Tolmetin Sodium is a non-steroidal anti-inflammatory drug.
References Elsabbagh, H. M., et al.: Int. J. Pharm. Res. Bio-Sci., 1 136 (2016)

Formula: C₁₅H₁₄NO₃·Na

Color and Shape: Neat

Molecular weight: 279.266

Ref: TR-T535375