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CAS 357166-30-4

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Pemetrexed disodium hydrate

Description:
Pemetrexed disodium hydrate is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, particularly non-small cell lung cancer and mesothelioma. It functions as an antifolate, inhibiting multiple enzymes involved in folate metabolism, which is crucial for DNA synthesis and cell division. The substance is a white to off-white crystalline powder that is soluble in water, which facilitates its administration in clinical settings. Its molecular structure includes a disodium salt form, enhancing its solubility and stability in solution. Pemetrexed disodium hydrate is typically administered intravenously and is often used in combination with other chemotherapy agents to improve therapeutic efficacy. Side effects may include fatigue, nausea, and myelosuppression, necessitating careful monitoring during treatment. The compound's mechanism of action and its role in cancer therapy underscore its importance in oncology, making it a significant focus of research and clinical application.
Formula:(C20H19N5Na2O6)·5(H2O)
InChI:InChI=1/C20H21N5O6.2Na.H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;1H2/q;2*+1;/p-2/t13-;;;/m0.../s1
Synonyms:
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate
  • Pemetrexed disodium 2.5H2O
  • 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt hydrate
  • Pemetrexed Disodium hemipenta hydrate
  • Pemetrexed disodium hemipentahydrate
  • Pemetrexed disodium hydrate
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