CAS 357275-54-8

Lopinavir Metabolite M-3/M-4

Description:

Lopinavir Metabolite M-3/M-4, identified by the CAS number 357275-54-8, is a chemical compound that serves as a metabolite of Lopinavir, an antiretroviral medication primarily used in the treatment of HIV/AIDS. This metabolite is formed through the metabolic processes in the body, particularly via cytochrome P450 enzymes. While specific physical and chemical properties such as melting point, boiling point, and solubility may not be widely documented, metabolites like M-3/M-4 typically exhibit altered pharmacological activity compared to their parent compounds. They may contribute to the overall therapeutic effects or side effects of the drug. The study of such metabolites is crucial for understanding drug metabolism, efficacy, and safety profiles. Additionally, the characterization of metabolites can aid in the development of more effective treatment regimens and the identification of potential drug interactions. Overall, Lopinavir Metabolite M-3/M-4 plays a significant role in the pharmacokinetics of Lopinavir and is of interest in pharmacological research.

Formula: C₃₇H₄₈N₄O₆

Synonyms:

• Lopinavir Impurity 23
• Lopinavir Metabolite M3-M4 (Mixture of Diastereomers)
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-4-hydroxy-α-(1-methylethyl)-2-oxo-, (αS)-
• (αS)-N-[(1S,3S,4S)-4-[[(2,6-DiMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-4-hydroxy-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidine-acetaMide
• Lopinavir 4-Hydroxy Analog
• Lopinavir M-3/M-4
• Lopinavir Metabolite

Lopinavir M-3/M-4

CAS: 357275-54-8

Lopinavir M-3/M-4 is a Lopinavir secondary metabolite.

Formula: C₃₇H₄₈N₄O₆

Color and Shape: Solid

Molecular weight: 644.8

Ref: TM-T32871

Lopinavir Metabolite M3-M4 (Mixture of Diastereomers)

CAS: 357275-54-8

Formula: C₃₇H₄₈N₄O₆

Color and Shape: Yellow Solid

Molecular weight: 644.81

Ref: 4Z-L-306

Lopinavir metabolite M-3/M-4

CAS: 357275-54-8

Lopinavir is an antiviral drug that inhibits HIV protease, an enzyme involved in the replication of the virus. It is metabolized to form M-3 and M-4, which are active against HIV protease. Lopinavir has been shown to have antiviral activities against HIV-1 and HIV-2. The activity of lopinavir against HIV protease may be due to its ability to bind to the active site of this enzyme and inhibit its catalytic activity.

Formula: C₃₇H₄₈N₄O₆

Purity: Min. 95%

Molecular weight: 644.8 g/mol

Ref: 3D-FL24928

Lopinavir Metabolite M-3/M-4

Controlled Product

CAS: 357275-54-8

Applications A major metabolite of Lopinavir (L469480) . It is a COVID19-related research product.
References Molla, A., et al.: J. Virology, 250, 255 (1998), Sham, H., et al.: Antimicrob. Agents Chemother., 42, 3218 (1998), Kumar, G., et al.: Drug Metab. Dispos., 27, 86 (1999),

Formula: C₃₇H₄₈N₄O₆

Color and Shape: Neat

Molecular weight: 644.80

Ref: TR-L469490