CAS 357400-13-6

[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] cyclopropanecarboxylate tetrahydrochloride

Description:

The chemical substance with the name "[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] cyclopropanecarboxylate tetrahydrochloride" and CAS number "357400-13-6" is a complex organic compound characterized by its multi-functional structure, which includes a tetralin core, a cyclopropanecarboxylate moiety, and a benzimidazole derivative. This compound exhibits properties typical of pharmaceuticals, including potential bioactivity due to its structural features that may interact with biological targets. The presence of a tetrahydrochloride salt form suggests enhanced solubility in aqueous environments, which is often beneficial for drug formulation. Its stereochemistry, indicated by the (1S,2S) configuration, may influence its pharmacokinetics and pharmacodynamics, affecting how the compound interacts with receptors or enzymes in biological systems. Overall, this substance is of interest in medicinal chemistry and pharmacology, particularly for its potential therapeutic applications. However, specific biological activity, toxicity, and detailed physicochemical properties would require further investigation through experimental studies.

Formula: C₃₀H₄₂Cl₄FN₃O₂

InChI: InChI=1/C30H38FN3O2.4ClH/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27;;;;/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33);4*1H/t28-,30-;;;;/m0..../s1

SMILES: CC(C)[C@H]1c2ccc(cc2CC[C@@]1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C1CC1)F.Cl.Cl.Cl.Cl

(1S,​2S)​-​2-​[2-​[[3-​(1H-​Benzimidazol-​2-​yl)​propyl]​methylamino]​ethyl]​-​6-​fluoro-​1,​2,​3,​4-​tetrahydro-​1-​(1-​methylethyl)​-​2-​naphthalenyl cyclopropanecarboxyl​ate dihydrochloride

CAS: 357400-13-6

Formula: C₃₀H₄₀Cl₂FN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 564.5619

Ref: IN-DA00C6GT

NNC 55-0396

CAS: 357400-13-6

NNC 55-0396

Purity: ≥95%

Molecular weight: 564.56g/mol

Ref: 54-BUP04080

(1S,2S)-2-(2-{[3-(1H-Benzimidazol-2-Yl)Propyl](Methyl)Amino}Ethyl)-6-Fluoro-1-Isopropyl-1,2,3,4-Tetrahydro-2-Naphthalenyl Cyclopropa necarboxylate Dihydrochloride

CAS: 357400-13-6

(1S,2S)-2-(2-{[3-(1H-Benzimidazol-2-Yl)Propyl](Methyl)Amino}Ethyl)-6-Fluoro-1-Isopropyl-1,2,3,4-Tetrahydro-2-Naphthalenyl Cyclopropa necarboxylate Dihydrochloride is an experimental drug that inhibits the activity of calcium ion channels. The cytosolic Ca2+ concentration is significantly decreased in cells incubated with this drug. This may be because the drug blocks the influx of extracellular Ca2+. The optimum concentration for this drug is 500 μM. It has been shown to inhibit neurotoxicity and cell apoptosis in nerve cells and spermatozoa.

Formula: C₃₀H₄₀Cl₂FN₃O₂

Purity: Min. 95%

Molecular weight: 564.56 g/mol

Ref: 3D-FB104200

NNC 55-0396

CAS: 357400-13-6

NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.

Formula: C₃₀H₄₀Cl₂FN₃O₂

Purity: 99.00%

Color and Shape: Solid

Molecular weight: 564.56

Ref: TM-T12238