CAS 35873-49-5

8-Cyclopentyltheophylline

Description:

8-Cyclopentyltheophylline is a chemical compound that belongs to the class of xanthine derivatives, which are known for their role as adenosine receptor antagonists. This substance is characterized by its structural modification of theophylline, where a cyclopentyl group is substituted at the 8-position of the xanthine ring. It exhibits properties that can influence various biological activities, particularly in the central nervous system and cardiovascular system, due to its ability to block adenosine receptors. The compound is often studied for its potential therapeutic effects, including its role in enhancing cognitive function and its implications in treating conditions like asthma and other respiratory disorders. In terms of physical properties, 8-Cyclopentyltheophylline is typically a solid at room temperature, with solubility characteristics that may vary depending on the solvent. Its pharmacological profile and mechanism of action make it a subject of interest in medicinal chemistry and pharmacology research.

Formula: C₁₂H₁₆N₄O₂

InChI: InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)

InChI key: InChIKey=SCVHFRLUNIOSGI-UHFFFAOYSA-N

SMILES: O=C1C2=C(N=C(N2)C3CCCC3)N(C)C(=O)N1C

Synonyms:

• 1,3-Dimethyl-8-Cyclopentylxanthine
• 1H-purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dimethyl-
• 1H-purine-2,6-dione, 8-cyclopentyl-3,9-dihydro-1,3-dimethyl-
• 8-Cyclopentyl-1,3-dimethylxanthine
• 8-Cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione
• 8-Cyclopentyltheophylline
• 8-cyclopentyl-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
• NSC 101806
• Pd 116600
• 8-Cyclopentyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

8-Cyclopentyl-1,3-dimethylxanthine

CAS: 35873-49-5

Formula: C₁₂H₁₆N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 248.2810

Ref: IN-DA00C90G

8-Cyclopentyl-1,3-dimethylxanthine

CAS: 35873-49-5

8-Cyclopentyl-1,3-dimethylxanthine

Purity: ≥95%

Molecular weight: 248.28g/mol

Ref: 54-BUP13622

8-Cyclopentyl-1,3-dimethylxanthine

CAS: 35873-49-5

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a potent antagonist of adenosine A1 receptor.

Formula: C₁₂H₁₆N₄O₂

Purity: 98.58% - >99.99%

Color and Shape: Solid

Molecular weight: 248.28

Ref: TM-T27076

8-Cyclopentyl-1,3-dimethylxanthine

CAS: 35873-49-5

Applications A selective A1 adenosine receptor antagonist. Binding activity in rat brain membranes: Ki = 10.9 nM (A1 receptor); Ki = 1440 nM (A2 receptor).
References Klaasse, E., et al.: Eur. J. Pharmacol., 499, 91 (2004), Romanelli, L., et al.: Neurotoxicol., 26, 829 (2005), Rezvani, M.E., et al.: Can. J. Physiol. Pharmacol., 85, 606 (2007),

Formula: C₁₂H₁₆N₄O₂

Color and Shape: Neat

Molecular weight: 248.28

Ref: TR-C988490

8-Cyclopentyl-1,3-dimethylxanthine

Controlled Product

CAS: 35873-49-5

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a xanthine derivative that binds to the adenosine receptor and inhibits the phosphodiesterase enzyme. CPT is used in vivo as a model for measuring locomotor activity, dopamine receptors, adenosine receptors, and glutamate receptors. The binding of CPT to these receptors can lead to bronchoconstriction by stimulating the release of vasoactive substances from airway cells and increasing the sensitivity of airway cells to bronchoconstrictor stimuli. This drug also has been shown to inhibit calcium ion influx into cytosol and increase intracellular levels of cAMP.

Formula: C₁₂H₁₆N₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 248.28 g/mol

Ref: 3D-FC20723

8-Cyclopentyl-1,3-dimethylxanthine

CAS: 35873-49-5

A selective A1 adenosine receptor antagonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₁₂H₁₆N₄O₂

Molecular weight: 248.28

Ref: 02-J61565