CAS 35891-70-4

(+)-Myriocin

Description:

(+)-Myriocin, also known as ISP-1, is a natural product derived from the fungus *Myriococcum albomyces*. It is classified as a sphingolipid synthesis inhibitor and is notable for its role in the study of sphingolipid metabolism. The compound exhibits a complex structure characterized by a long aliphatic chain and multiple functional groups, which contribute to its biological activity. (+)-Myriocin is primarily recognized for its immunosuppressive properties, making it of interest in pharmacological research, particularly in the context of transplant rejection and autoimmune diseases. It functions by inhibiting serine palmitoyltransferase, an enzyme crucial for the biosynthesis of sphingolipids, thereby affecting cell signaling and proliferation. In addition to its therapeutic potential, (+)-Myriocin has been studied for its effects on various cellular processes, including apoptosis and inflammation. Its unique properties and mechanisms of action continue to be explored in both basic and applied research settings.

Formula: C₂₁H₃₉NO₆

InChI: InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1

InChI key: InChIKey=ZZIKIHCNFWXKDY-GNTQXERDSA-N

SMILES: [C@]([C@H]([C@@H](C/C=C/CCCCCCC(CCCCCC)=O)O)O)(C(O)=O)(CO)N

Synonyms:

• (+)-Myriocin
• (2R,3S,4S,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid
• (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid
• (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
• (E,2R,3S,4S)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-icos-6-enoic acid
• 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3R,4R,6E)-
• 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, [2S-(2R*,3S*,4S*,6E)]-
• 6-eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2R,3S,4S,6E)-
• Isp-I
• NSC 177379
• Thermozymocidin

(E,2R,3S,4S)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid

CAS: 35891-70-4

Formula: C₂₁H₃₉NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 401.5375

Ref: IN-DA00I743

Myriocin

CAS: 35891-70-4

Myriocin (Thermozymocidin) is a SPT inhibitor derived from Myriococcum albomyces with antiparasitic activity and can be used in the study of neuropathy.

Formula: C₂₁H₃₉NO₆

Purity: >99.99% - >99.99%

Color and Shape: Solid

Molecular weight: 401.54

Ref: TM-T16165

Myriocin from Mycelia sterilia

CAS: 35891-70-4

Myriocin from Mycelia sterilia

Formula: C₂₁H₃₉NO₆

Purity: 99% (tlc) (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 401.54g/mol

Ref: 54-BIM1005

Myriocin

CAS: 35891-70-4

Formula: C₂₁H₃₉NO₆

Purity: ≥ 98%

Color and Shape: White or almost white powder

Molecular weight: 401.54

Ref: 7W-GL9729

Myriocin

CAS: 35891-70-4

Myriocin is a potent fungal metabolite that is an inhibitor of sphingolipid biosynthesis. It is originally sourced from the ascomycete fungus *Isaria* sinclairii. Myriocin functions by specifically inhibiting serine palmitoyltransferase, the key enzyme in the de novo sphingolipid biosynthesis pathway, effectively reducing the production of ceramides and sphingomyelins. This mechanism of action makes Myriocin a significant tool in the study of sphingolipid metabolism and signaling pathways.

Formula: C₂₁H₃₉NO₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 401.54 g/mol

Ref: 3D-AM57735