CAS 35943-35-2

Triciribine

Description:

Triciribine, also known by its chemical name 2-amino-5-(4-(2-(4-(2-amino-1,2-dihydro-3H-pyrrolo[3,4-b]quinolin-1-yl)ethyl)phenyl)-1H-pyrazol-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid, is a synthetic compound primarily studied for its potential therapeutic applications, particularly in oncology. It is recognized as a protein kinase inhibitor, specifically targeting the Akt pathway, which plays a crucial role in cell survival and proliferation. Triciribine has been investigated for its ability to induce apoptosis in cancer cells and enhance the efficacy of other anticancer agents. The compound is characterized by its complex molecular structure, which includes multiple aromatic rings and functional groups that contribute to its biological activity. In terms of solubility, Triciribine exhibits moderate solubility in organic solvents, but its solubility in water is limited, which can affect its bioavailability. As research continues, the pharmacokinetics, safety profile, and full therapeutic potential of Triciribine are subjects of ongoing investigation.

Formula: C₁₃H₁₆N₆O₄

InChI: InChI=1/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)

InChI key: InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N

SMILES: NC=1C=2C=3C(N(C2)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)=NC=NC3N(C)N1

Synonyms:

• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-
• 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacennaphthylen-3-amine
• 1,5-Dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 35943-35-2
• 5-Methyl-1-Pentofuranosyl-1,5-Dihydro-1,4,5,6,8-Pentaazaacenaphthylen-3-Amine
• 5-Methyl-1-b-D-ribofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 5-methyl-1-(beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 6-Amino-4-methyl-8-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine
• AKT Inhibitor V
• Api-2
• NSC 154020
• Triciribidine
• 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• Triciribine
• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-
• 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine
• Triciribine hydrate
• RNF49
• Anti-Myosin ia
• TRICYCLIC NUCLEOSIDE
• MYO1A
• VD-0002
• Anti-MYO1A antibody produced in rabbit
• TCN
• Anti-Myhl
• 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
• 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
• IAP1
• 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
• Brush border myosin I
• 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
• AKT/PKB SIGNALING INHIBITOR-2
• hthylene
• ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
• 3-amine
• pentaazacentopthylene
• API-2 (Tricirbine)
• (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
• Myosin-Ia
• ANTI-MYO1A (CENTER S291) antibody produced in rabbit
• Anti-Dfna48
• DFNA48
• MIHC
• 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
• 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
• MYHL
• Inhibitor V
• 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
• BBMI
• BIRC3
• uranosyl-
• nosyl-

API-2

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 320.3039

Ref: IN-DA00C0BN

Triciribine

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄·xH₂O

Molecular weight: 320.30 (anhydrous)

Ref: 7W-GN7110

Triciribine

CAS: 35943-35-2

Triciribine

Purity: ≥98%

Molecular weight: 320.3g/mol

Ref: 54-BUP04786

(2R,3R,4S,5R)-2-(3-Amino-5-Methyl-1,4,5,6,8-Pentaazaacenaphthylen-1(5H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

CAS: 35943-35-2

(2R,3R,4S,5R)-2-(3-Amino-5-Methyl-1,4,5,6,8-Pentaazaacenaphthylen-1(5H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

Purity: 98%

Molecular weight: 320.3g/mol

Ref: 54-OR1023082

Tricirbine-13C5

CAS: 35943-35-2

Formula: C₅C₈H₁₆N₆O₄

Molecular weight: 325.25

Ref: 4Z-T-166003

Triciribine

CAS: 35943-35-2

Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.

Formula: C₁₃H₁₆N₆O₄

Purity: 99.01% - 99.87%

Color and Shape: Solid

Molecular weight: 320.3

Ref: TM-T6065

Tricirbine

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄

Molecular weight: 320.31

Ref: 4Z-T-166001

Triciribine

CAS: 35943-35-2

Protein kinase B inhibitor;

Formula: C₁₃H₁₆N₆O₄

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 320.3 g/mol

Ref: 3D-NT08796

Triciribine

Controlled Product

CAS: 35943-35-2

Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);

Formula: C₁₃H₁₆N₆O₄

Color and Shape: Neat

Molecular weight: 320.30

Ref: TR-T774245