CAS 35959-38-7

1-(5-amino-2,5-dideoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione

Description:

1-(5-amino-2,5-dideoxypentofuranosyl)pyrimidine-2,4(1H,3H)-dione, with the CAS number 35959-38-7, is a nucleoside analog that features a pyrimidine base linked to a modified sugar moiety. This compound is characterized by the presence of an amino group at the 5-position of the sugar, which contributes to its biological activity. The dideoxypentofuranosyl structure indicates that it lacks hydroxyl groups at the 2' and 5' positions, which is significant for its stability and interaction with nucleic acid synthesis pathways. The pyrimidine-2,4-dione moiety suggests that it may exhibit tautomeric forms, influencing its reactivity and binding properties. This compound is of interest in medicinal chemistry, particularly in the development of antiviral and anticancer agents, as it can interfere with nucleic acid metabolism. Its unique structural features may also allow for selective targeting of specific enzymes or pathways in cellular processes. Overall, this compound exemplifies the intricate relationship between structure and function in nucleoside analogs.

Formula: C₉H₁₃N₃O₄

InChI: InChI=1/C9H13N3O4/c10-4-6-5(13)3-8(16-6)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4,10H2,(H,11,14,15)

SMILES: c1cn(C2CC(C(CN)O2)O)c(=O)nc1O

Synonyms:

• 2,4(1H,3H)-pyrimidinedione, 1-(5-amino-2,5-dideoxypentofuranosyl)-
• 5'-Amino-2',5'-dideoxyuridine
• Uridine, 5'-amino-2',5'-dideoxy-

5'-Amino-2',5'-dideoxyuridine

CAS: 35959-38-7

5'-Amino-2',5'-dideoxyuridine is a Nucleoside Derivative - 5'-Deoxy nucleoside; 5'-Modified nucleoside; Amino nucleoside.

Formula: C₉H₁₃N₃O₄

Color and Shape: Solid

Molecular weight: 227.22

Ref: TM-TNU1252

5'-Amino-2',5'-dideoxyuridine

CAS: 35959-38-7

5'-Amino-2',5'-dideoxyuridine (5-ADU) is a pyrimidine nucleoside that is structurally similar to thymidylate, which it inhibits. 5-ADU is used in the treatment of viral infections and cancers, as well as in the prevention of radiation injury. It has been shown to be an effective antiviral agent against herpes virus and some DNA viruses, such as adenovirus, vaccinia virus, and poliovirus. 5-ADU also enhances the effects of azauridine and other pyrimidine nucleosides in bacterial enzymes such as E. coli. 5-ADU has not been shown to be active against uninfected cells or tissues.

Formula: C₉H₁₃N₃O₄

Purity: Min. 95%

Molecular weight: 227.22 g/mol

Ref: 3D-NA163153