CAS 3599-32-4

Indocyanine green

Description:

Indocyanine green (ICG) is a synthetic dye primarily used in medical diagnostics, particularly in ophthalmology and cardiovascular imaging. It is characterized by its dark green color and strong absorption in the near-infrared region of the electromagnetic spectrum, making it particularly useful for fluorescence imaging. The chemical structure of ICG includes a cyanine dye backbone, which contributes to its unique optical properties. ICG is water-soluble and has a relatively low toxicity profile, which enhances its suitability for clinical applications. Upon administration, it binds to plasma proteins, allowing for effective visualization of blood flow and tissue perfusion. Its rapid clearance from the bloodstream, primarily through the liver, is another notable characteristic. Additionally, ICG is used in various applications beyond imaging, including assessing liver function and guiding surgical procedures. Overall, its distinctive properties make Indocyanine green a valuable tool in both diagnostic and therapeutic settings.

Formula: C₄₃H₄₇N₂NaO₆S₂

InChI: InChI=1/C43H48N2O6S2.Na/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-52(46,47)48)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1/rC43H47N2NaO6S2/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-53(47,48)49)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-54(50,51)52-46/h5-13,18-27H,14-17,28-31H2,1-4H3

InChI key: InChIKey=AANGVCDSLQANGQ-UHFFFAOYSA-N

SMILES: CC1(C)C2=C([N+](CCCCS(=O)(=O)[O-])=C1C=CC=CC=CC=C3N(CCCCS(=O)(=O)O)C4=C(C3(C)C)C=5C(C=C4)=CC=CC5)C=CC=6C2=CC=CC6.[Na]

Synonyms:

• 1H-Benz[e]indolium, 2-[7-[1,1-dimethyl-3-(4-sulfobutyl)benz[e]indolin-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt (1:1)
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, hydroxide, inner salt, sodium salt
• 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt
• 2-{7-[1,3-Dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]hepta-1,3,5-trienyl}-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz[e]indolium, hydroxyde, sel interne, sel de sodium
• 4,5-Benzoindotricarbocyanine
• 4-[(2Z)-2-[(2Z,4E,6Z)-7-[3,3-dimethyl-1-(4-sulfonatobutyl)benzo[g]indol-1-ium-2-yl]hepta-2,4,6-trienylidene]-3,3-dimethyl-benzo[g]indol-1-yl]butylsulfonyloxysodium
• Cardio Green
• HWD Indocyanine Green
• ICG
• Indocyanin green
• Ir-125
• Natrium-2-[7-[3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolin-2-yliden]hepta-1,3,5-trien-1-yl]-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
• Nk 2611
• Nk 2612
• Opthagreen
• Sacarosa, Bruta (De Cana)
• Saccharose, Brut (De Canne)
• So 270
• Sodium 2-(7-(3,3-Dimethyl-1-(4-Sulfonatobutyl)Benz(E)Indolin-2-Ylidene)Hepta-1,3,5-Trien-Y-1-Yl)-3,3-Dimethyl-1-(4-Sulfonatobutyl)Benz[E]Indolinium
• Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
• Ujoviridin
• Wofaverdin
• sodium 4-(2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indolium-2-yl]hepta-2,4,6-trien-1-ylidene}-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate
• 4-(2-[7-[1,1-DIMETHYL-3-(4-SULFO-BUTYL)-1H-BENZO[E]INDOL-2-YL]-HEPTA-2,4,6-TRIENYLIDENE]-1,1-DIMETHYL-BENZO[E]INDOLIUM-3-YL)-BUTANE-1-SULFONIC ACID SODIUM SALT
• )-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-,hydroxide,innersalt,
• CARDIOGREEN
• BIS-[1-(4-SULFOBUTYL)-3,3-DIMETHYL-4,5-BENZOINDOLINYLIDEN-2]-HEPTAMETHINECYANINE-BETAINE-SODIUM SALT (INDOCYANINEGREEN, CARDIOGREEN)
• FOXGREEN
• IC GREEN
• INDOCYANINE GREEN
• ,innersalt,sodiumsalt(9ci)

Indocyanine Green

CAS: 3599-32-4

Synthetic organic coloring matter,nesoi

Formula: C₄₃H₄₇N₂NaO₆S₂

Color and Shape: Green Brown Blue Powder

Molecular weight: 774.27732

Ref: 45-1340009

1H-Benz[e]indolium,2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodiumsalt

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 774.9629

Ref: IN-DA00I74W

Indocyanine green

CAS: 3599-32-4

Indocyanine green

Purity: ≥98%

Molecular weight: 774.96g/mol

Ref: 54-BUP17455

Cardio-Green

CAS: 3599-32-4

Cardio-Green

Purity: 97%

Molecular weight: 774.96g/mol

Ref: 54-OR1012625

Indocyanine Green

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂O₆S₂·Na

Molecular weight: 751.98 22.99

Ref: 4Z-I-134001

Cardiogreen, 95%, USP grade

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purity: 90.0 - 105.0 % (dried basis)

Color and Shape: Dark green to brown crystalline powder

Molecular weight: 774.96

Ref: 7W-GT1101

Indocyanine green

CAS: 3599-32-4

Indocyanine green (Cardiogreen) is a low toxicic fluorescent agent, is a tricarbocyanine dye,has been widely used in medical diagnostics.

Formula: C₄₃H₄₇N₂NaO₆S₂

Purity: ≥98%

Color and Shape: Green To Green With A Brown Cast Powder

Molecular weight: 774.96

Ref: TM-T14875

Indocyanine Green-d12

CAS: 3599-32-4

Formula: C₄₃H₃₅D₁₂N₂O₆S₂·Na

Molecular weight: 764.05 22.99

Ref: 4Z-I-134002

Cardiogreen

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Purity: ≥ 90.0%

Color and Shape: Dark green powder

Molecular weight: 774.96

Ref: 7W-GT1409

Indocianine Green RS

CAS: 3599-32-4, 7681-82-5

Color and Shape: Dark Greenish Blue Solid Powder

Ref: 2K-2001000021

Indocyanine Green (~90%)

Controlled Product

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂O₆S₂·Na

Purity: ~90%

Color and Shape: Neat

Molecular weight: 774.96

Ref: TR-I697000

Indocyanine green

CAS: 3599-32-4

Indocyanine green is a fluorescent dye with a variety of applications in medical imaging. It has been used to diagnose and evaluate the activity of cancer cells and brain functions. Indocyanine green has also been used as an angiographic agent for diagnosis of solid tumours. In addition, it can be used to evaluate liver function and the blood flow in the brain. The biological properties of indocyanine green have not yet been fully elucidated, but it is known that it binds to hepatocyte-like cells in culture and is found at high levels in human serum. This dye shows fluorescence when bound to DNA or RNA, which indicates its possible use as a molecular probe for detecting carcinoma cells. 
Indocyanine green is a STT3B inhibitor and has been shown to prevent α-amanitin toxicity in mice (Wang et al, 2023). This means it could be a possible antidote to poisoning by Amanita, such as death cap mushroom Amanita phalloides, which is the cause of over 90% of fatal mushroom poisoning.

Formula: C₄₃H₄₇N₂O₆S₂·Na

Purity: (%) Min. 95%

Color and Shape: Green Powder

Molecular weight: 774.96 g/mol

Ref: 3D-FI10558

Indocyanine Green >d6

Controlled Product

CAS: 3599-32-4

Applications It is the labeled analogue of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).
References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003),

Formula: C₇H₁₄N₂O

Color and Shape: Neat

Molecular weight: NA

Ref: TR-I697003

Indocyanine Green

CAS: 3599-32-4

Formula: C₄₃H₄₇N₂NaO₆S₂

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 774.97

Ref: 3B-I0535

Indocyanine green

CAS: 3599-32-4

Purity: 95%

Molecular weight: 774.97

Ref: 10-F868901