CAS 36084-18-1

Cytochalasin F

Description:

Cytochalasin F is a naturally occurring compound classified as a cytochalasins, which are a group of fungal metabolites known for their ability to disrupt cytoskeletal functions. It is derived from the fungus *Helminthosporium* and is recognized for its potent effects on cell motility and division. Cytochalasin F primarily acts by inhibiting the polymerization of actin filaments, leading to alterations in cell shape and movement. This compound exhibits a complex structure characterized by a macrocyclic lactone and a unique side chain, contributing to its biological activity. In laboratory settings, Cytochalasin F is utilized as a research tool to study cellular processes such as cytokinesis, endocytosis, and cell signaling pathways. Its effects are dose-dependent, and it is important to handle it with care due to its potential cytotoxicity. Additionally, Cytochalasin F has been investigated for its potential therapeutic applications, although further research is necessary to fully understand its mechanisms and effects in various biological contexts.

Formula: C₂₉H₃₇NO₅

InChI: InChI=1/C29H37NO5/c1-18-9-7-13-21(31)15-16-24(32)34-29-22(14-8-10-18)26-28(3,35-26)19(2)25(29)23(30-27(29)33)17-20-11-5-4-6-12-20/h4-6,8,11-12,14-16,18-19,21-23,25-26,31H,7,9-10,13,17H2,1-3H3,(H,30,33)/b14-8+,16-15+/t18-,19+,21-,22+,23+,25+,26+,28-,29-/m1/s1

Synonyms:

• Cytochalasin F
• 3H-Oxacyclotetradecino[2,3-d]oxireno[f]isoindole-11,13(4H,14H)-dione, 5,6,7,8,15,15a,16,16a,17a,17b-decahydro-8-hydroxy-4,16,16a-trimethyl-15-(phenylmethyl)-, (1E,4R,8R,9E,12aS,15S,15aS,16S,16aR,17aS,17bS)-
• (7S,13E,16R,20R,21E)-6,7-Epoxy-20-hydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-13,21-diene-1,23-dione
• 24-Oxa[14]cytochalasa-13,21-diene-1,23-dione, 6,7-epoxy-20-hydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
• (1E,4R,8R,9E,12aS,15S,15aS,16S,16aR,17aS,17bS)-5,6,7,8,15,15a,16,16a,17a,17b-Decahydro-8-hydroxy-4,16,16a-trimethyl-15-(phenylmethyl)-3H-oxacyclotetradecino[2,3-d]oxireno[f]isoindole-11,13(4H,14H)-dione
• 3H-Oxacyclotetradecino[2,3-d]oxireno[f]isoindole, 24-oxa[14]cytochalasa-13,21-diene-1,23-dione deriv.
• 3H-oxacyclotetradecino[2,3-d]oxireno[f]isoindole-11,13(4H,14H)-dione, 5,6,7,8,15,15a,16,16a,17a,17b-decahydro-8-hydroxy-4,16,16a-trimethyl-15-(phenylmethyl)-, (1E,4R,8R,9E,12aS,15S,15aS,16S,16aR,17aS,17bS)-

Cytochalasin F

CAS: 36084-18-1

Cytochalasin F reversibly inhibits cytokinesis and possesses various biological activities including the inhibition of macrophage endocytosis and exocytosis.

Formula: C₂₉H₃₇NO₅

Color and Shape: Solid

Molecular weight: 479.608

Ref: TM-TN10033