CAS 36112-95-5

Propranolol glycol

Description:

Propranolol glycol, identified by its CAS number 36112-95-5, is a derivative of propranolol, a non-selective beta-adrenergic antagonist commonly used to treat various cardiovascular conditions, anxiety, and migraine prophylaxis. This compound is characterized by its ability to inhibit the action of catecholamines on beta receptors, leading to effects such as decreased heart rate and blood pressure. Propranolol glycol is typically a white to off-white crystalline powder, exhibiting moderate solubility in water and organic solvents, which facilitates its formulation in pharmaceutical preparations. The substance may also possess a range of pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, similar to its parent compound, propranolol. Its safety profile and potential side effects are generally aligned with those of propranolol, necessitating careful consideration in clinical use. As with any pharmaceutical compound, proper handling and storage conditions are essential to maintain its stability and efficacy.

Formula: C₁₃H₁₄O₃

InChI: InChI=1/C13H14O3/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,14-15H,8-9H2

InChI key: InChIKey=BYNNMWGWFIGTIC-UHFFFAOYSA-N

SMILES: O(CC(CO)O)C=1C2=C(C=CC1)C=CC=C2

Synonyms:

• 1,2-Propanediol, 3-(1-naphthalenyloxy)-
• 1,2-Propanediol, 3-(1-naphthyloxy)-
• 1-(α-Naphthoxy)-2,3-propylene glycol
• 3-(1-Naphthalenyloxy)-1,2-propanediol
• 3-(1-Naphthyloxy)propane-1,2-diol
• 3-(α-Naphthoxy)-1,2-propanediol
• 3-(α-Naphthoxy)-1,2-propylene glycol
• Propranolol glycol
• 3-(naphthalen-1-yloxy)propane-1,2-diol
• Propanolol glycol
• 3-(1-Naphtyloxy)propane-1,2-diol
• Propranolol Hydrochloride EP Impurity A
• Propranolol iMpurity A, diol derivative
• 1,2-Dihydroxy-3-(1-naphthoxy)propane
• 3-(1-Naphthyloxy)-1,2-propanediol
• Propranolol Impurity A
• Propranolol EP Impurity A (Propranolol Diol Derivative)
• (2RS)-3-(Naphthalen-1-yloxy)propane
• Propranolol EP impurity A
• Propranolol HCl impurity A
• Propranolol-1

Propranolol Related Compound A (3-(Naphthalen-1-yloxy)propane-1,2-diol)

CAS: 36112-95-5

Ether-alcohols and their halogenated, sulfonated, nitrated or nitrosated derivatives not elsewhere specified or included

Formula: C₁₃H₁₄O₃

Color and Shape: White Powder

Molecular weight: 218.09429

Ref: 45-1576016

Propranolol EP Impurity A (Propranolol USP Related Compound A, Propranolol Diol Derivative)

CAS: 36112-95-5

Formula: C₁₃H₁₄O₃

Color and Shape: Off-White Solid

Molecular weight: 218.25

Ref: 4Z-P-1611

(2RS)-3-(Naphthalen-1-yloxy)propane-1,2-diol (Diol Derivative)

Controlled Product

CAS: 36112-95-5

Formula: C₁₃H₁₄O₃

Color and Shape: Neat

Molecular weight: 218.25

Ref: 86-MM0043.01

Propranolol EP Impurity A

CAS: 36112-95-5

Formula: C₁₃H₁₄O₃

Molecular weight: 218.25

Ref: ST-EA-CP-P31001

3-(1-Naphthalenyloxy)-1,2-propanediol

Controlled Product

CAS: 36112-95-5

Applications 3-(1-Naphthalenyloxy)-1,2-propanediol is an impurity of Propranolol (P831800), an β−Adrenergic blocker used as a antihypertensive and antilanginal agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Semple, H.A., et al.: Drug. Metabolism. Dispost., 23, 794 (1995); Liedholm, H., et al.: Euro. J. Clin. Pharmacol., 38, 469 (1990);

Formula: C₁₃H₁₄O₃

Color and Shape: White

Molecular weight: 218.25

Ref: TR-N359320

PROPRANOLOL GLYCOL

CAS: 36112-95-5

Purity: 98%

Molecular weight: 218.2519989

Ref: 10-F816159

Propranolol glycol

CAS: 36112-95-5

Propranolol is a beta-adrenergic receptor antagonist that blocks the binding of epinephrine (adrenaline) or norepinephrine to these receptors. It is used in the treatment of hypertension, angina, and other cardiac disorders. Propranolol hydrolyzes in vivo to produce its active form, propranolol glycol. The enzyme responsible for this hydrolysis is unknown. It has been shown that propranolol glycol can be detected in urine samples after oral administration as well as by fluorescence detection methods. Propranolol glycol has been found to be an effective inhibitor of carboxypeptidase A2, an enzyme involved in the metabolism of drugs such as morphine and cephalosporin C.
Propranolol Glycol is a beta-adrenergic receptor antagonist that blocks the binding of epinephrine (adrenaline) or norepinephrine to these receptors. It is used in

Formula: C₁₃H₁₄O₃

Purity: Min. 95%

Molecular weight: 218.25 g/mol

Ref: 3D-LBA11295