CAS 361442-04-8: Saxagliptin

Description: Saxagliptin is an oral antihyperglycemic agent belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, primarily used in the management of type 2 diabetes mellitus. Its mechanism of action involves the inhibition of the DPP-4 enzyme, which leads to increased levels of incretin hormones, thereby enhancing insulin secretion and reducing glucagon levels in a glucose-dependent manner. Saxagliptin is characterized by its chemical formula, which includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. The substance is typically administered in tablet form and is known for its relatively favorable safety profile, although it may be associated with some side effects such as upper respiratory tract infections and gastrointestinal disturbances. Saxagliptin is often used in combination with other antidiabetic medications to achieve better glycemic control. Its efficacy and safety have been established through various clinical trials, making it a valuable option in diabetes management.

Formula: C₁₈H₂₅N₃O₂

InChI: InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1

InChI key: InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N

SMILES: N#CC1N(C(=O)C(N)C23CC4CC(CC(O)(C4)C2)C3)C5CC5C1

Synonyms:

• (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• (1S,3S,5S)-2-[2(S)-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
• Bms 477118
• Bms 477118-11
• Onglyza
• Saxagliptin
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-

Saxagliptin

CAS: 361442-04-8

• Purity: 98%
• Molecular weight: 315.41g/mol

Saxagliptin

CAS: 361442-04-8

• Formula: C₁₈H₂₅N₃O₂
• Molecular weight: 315.41

Saxagliptin-13C-d2 HCl

CAS: 361442-04-8

• Formula: C₁₇₁₃CH₂₃D₂N₃O₂·HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 318.42 36.46

Saxagliptin

CAS: 361442-04-8

• Formula: C₁₈H₂₅N₃O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 315.42

Saxagliptin

CAS: 361442-04-8

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Color and Shape: White to off-white, Crystalline powder

Saxagliptin

CAS: 361442-04-8

• Formula: C₁₈H₂₅N₃O₂
• Color and Shape: Neat
• Molecular weight: 315.41

Saxagliptin Impurity 18

CAS: 361442-04-8

• Formula: C₁₇H₂₅N₃O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 303.41

Saxagliptin

CAS: 361442-04-8

Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

• Formula: C₁₈H₂₅N₃O₂
• Purity: 98.05% - 99.95%
• Color and Shape: Solid
• Molecular weight: 315.41

Saxagliptin

CAS: 361442-04-8

Stability Temperature Sensitive Applications Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, …

• Formula: C₁₈H₂₅N₃O₂
• Color and Shape: White Solid
• Molecular weight: 315.41

Saxagliptin

CAS: 361442-04-8

DPP-4 enzyme inhibitor; anti-diabetic

• Formula: C₁₈H₂₅N₃O₂
• Color and Shape: White Powder
• Molecular weight: 315.41 g/mol

(S)-1-((S)-2-Amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2,3-dihydro-1H-pyrrole-2-carboxamide

CAS: 361442-04-8

• Formula: C₁₇H₂₅N₃O₃
• Color and Shape: Neat
• Molecular weight: 319.399