CAS 361442-04-8
:Saxagliptin
Description:
Saxagliptin is an oral antihyperglycemic agent belonging to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, primarily used in the management of type 2 diabetes mellitus. Its mechanism of action involves the inhibition of the DPP-4 enzyme, which leads to increased levels of incretin hormones, thereby enhancing insulin secretion and reducing glucagon levels in a glucose-dependent manner. Saxagliptin is characterized by its chemical formula, which includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. The substance is typically administered in tablet form and is known for its relatively favorable safety profile, although it may be associated with some side effects such as upper respiratory tract infections and gastrointestinal disturbances. Saxagliptin is often used in combination with other antidiabetic medications to achieve better glycemic control. Its efficacy and safety have been established through various clinical trials, making it a valuable option in diabetes management.
Formula:C18H25N3O2
InChI:InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1
InChI key:InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N
SMILES:[C@H](C(=O)N1[C@@]2([C@@](C2)(C[C@H]1C#N)[H])[H])(N)C34CC5(O)CC(C3)CC(C4)C5
Synonyms:- (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1<sup>3,7</sup>]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- (1S,3S,5S)-2-[2(S)-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1<sup>3,7</sup>]dec-1-yl)acetyl]-, (1S,3S,5S)-
- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3.1.1<sup>3,7</sup>]dec-1-yl)acetyl]-, (1S,3S,5S)-
- Bms 477118
- Bms 477118-11
- Onglyza
- Saxagliptin
- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
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Found 11 products.
Saxagliptin-13C-d2 HCl
CAS:Formula:C1713CH23D2N3O2·HClColor and Shape:White To Off-White SolidMolecular weight:318.42 36.46Saxagliptin Impurity 18
CAS:Formula:C17H25N3O2Color and Shape:White To Off-White SolidMolecular weight:303.41Saxagliptin
CAS:<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Formula:C18H25N3O2Purity:99.17% - 99.95%Color and Shape:SolidMolecular weight:315.41Saxagliptin
CAS:Controlled Product<p>Stability Temperature Sensitive<br>Applications Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.<br>References Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),<br></p>Formula:C18H25N3O2Color and Shape:White SolidMolecular weight:315.41Saxagliptin
CAS:<p>DPP-4 enzyme inhibitor; anti-diabetic</p>Formula:C18H25N3O2Color and Shape:White PowderMolecular weight:315.41 g/mol(S)-1-((S)-2-Amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2,3-dihydro-1H-pyrrole-2-carboxamide
CAS:Controlled ProductFormula:C17H25N3O3Color and Shape:NeatMolecular weight:319.399
