CAS 361444-66-8
:JDTic
Description:
JDTic, with the CAS number 361444-66-8, is a chemical compound known for its role as a selective antagonist of the kappa-opioid receptor (KOR). It is a synthetic derivative of the morphinan class of compounds and has garnered interest in pharmacological research due to its potential therapeutic applications, particularly in the treatment of addiction and mood disorders. JDTic exhibits high affinity for KORs, which are G-protein coupled receptors involved in pain modulation, stress response, and mood regulation. The compound's structure features a unique arrangement of functional groups that contribute to its receptor selectivity and biological activity. In preclinical studies, JDTic has shown promise in reducing drug-seeking behavior and alleviating symptoms associated with stress and anxiety. However, further research is necessary to fully understand its pharmacokinetics, safety profile, and potential clinical applications. As with many experimental compounds, the exploration of JDTic's effects continues to evolve within the context of neuropharmacology and addiction treatment.
Formula:C28H39N3O3
InChI:InChI=1S/C28H39N3O3/c1-18(2)26(30-27(34)25-13-20-8-9-24(33)12-21(20)15-29-25)17-31-11-10-28(4,19(3)16-31)22-6-5-7-23(32)14-22/h5-9,12,14,18-19,25-26,29,32-33H,10-11,13,15-17H2,1-4H3,(H,30,34)/t19-,25+,26+,28+/m0/s1
InChI key:InChIKey=ZLVXBBHTMQJRSX-VMGNSXQWSA-N
SMILES:C[C@@]1([C@@H](C)CN(C[C@@H](NC(=O)[C@H]2CC=3C(CN2)=CC(O)=CC3)C(C)C)CC1)C4=CC(O)=CC=C4
Synonyms:- 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)-
- JDTic
- (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide
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JDTic
CAS:<p>JDTic, a 4-phenylpiperidine derivative distantly related to analgesics like meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan, exhibits a notably long duration of action, maintaining effects in animals for weeks following a single dose. This duration is not due to irreversible binding to the kappa opioid receptor but rather to altered activity of c-Jun N-terminal kinases. As a highly selective antagonist for the κ-opioid receptor, without influencing the μ- or δ-opioid receptors, JDTic has shown potential in animal studies for producing antidepressant and anxiolytic effects. It also demonstrates promise in treating addiction to substances such as cocaine and morphine, distinguishing itself structurally from other kappa antagonists like norbinaltorphimine.</p>Formula:C28H39N3O3Color and Shape:SolidMolecular weight:465.63
