CAS 36167-63-2: (±)-Halofantrine hydrochloride
Description:(±)-Halofantrine hydrochloride is a synthetic antimalarial agent primarily used in the treatment of malaria caused by Plasmodium falciparum. It is characterized by its complex chemical structure, which includes a phenanthrene backbone and a piperidine moiety. The substance is typically presented as a hydrochloride salt, enhancing its solubility in aqueous solutions. Halofantrine exhibits a mechanism of action that involves interference with the heme detoxification process in the malaria parasite, leading to the accumulation of toxic heme and ultimately causing parasite death. The compound is known for its relatively high lipophilicity, which influences its pharmacokinetics, including absorption and distribution in the body. However, it is important to note that (±)-Halofantrine can have significant side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. The compound is classified under the category of antimalarial drugs and is subject to regulatory controls due to its potential for adverse effects and interactions with other medications.
Formula:C26H30Cl2F3NO·ClH
InChI:InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
InChI key:InChIKey=WANGFTDWOFGECH-UHFFFAOYSA-N
SMILES:Cl.FC(F)(F)C1=CC=C2C(=C1)C=3C=C(Cl)C=C(Cl)C3C=C2C(O)CCN(CCCC)CCCC
- Synonyms:
- (Dibutylamino)Ethyl)-6-(Trifluoromethyl)-9-Phenanthrenemethanol Hydrochloride
- 1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl
- 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride
- 1,3-Dichloro-alpha-(2-1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride
- 1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride
- 3-(Dibutylamino)-1-[1,3-Dichloro-6-(Trifluoromethyl)Phenanthren-9-Yl]Propan-1-Ol Hydrochloride (1:1)
- 9-(3-(Dibutylamino)-1-Hydroxypropyl)-1,3-Dichloro-6-(Trifluoromethyl)Phenanthrene Hydrochloride
- 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride
- 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride
- 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride (1:1)
- See more synonyms
- Halofantrine Hcl
- Halofantrine Hydrochloride [USAN]
- Halofantrino
- Halofantrino [Spanish]
- Skf 102886
- Unii-H77Dl0Y630
- Wr 171669
- (+-)-Halofantrine hydrochloride
- (±)-Halofantrine hydrochloride
