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CAS 36167-63-2

:

(±)-Halofantrine hydrochloride

Description:
(±)-Halofantrine hydrochloride is a synthetic antimalarial agent primarily used in the treatment of malaria caused by Plasmodium falciparum. It is characterized by its complex chemical structure, which includes a phenanthrene backbone and a piperidine moiety. The substance is typically presented as a hydrochloride salt, enhancing its solubility in aqueous solutions. Halofantrine exhibits a mechanism of action that involves interference with the heme detoxification process in the malaria parasite, leading to the accumulation of toxic heme and ultimately causing parasite death. The compound is known for its relatively high lipophilicity, which influences its pharmacokinetics, including absorption and distribution in the body. However, it is important to note that (±)-Halofantrine can have significant side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. The compound is classified under the category of antimalarial drugs and is subject to regulatory controls due to its potential for adverse effects and interactions with other medications.
Formula:C26H30Cl2F3NO·ClH
InChI:InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
InChI key:InChIKey=WANGFTDWOFGECH-UHFFFAOYSA-N
SMILES:C(CCN(CCCC)CCCC)(O)C1=C2C(=C3C(=C1)C(Cl)=CC(Cl)=C3)C=C(C(F)(F)F)C=C2.Cl
Synonyms:
  • (Dibutylamino)Ethyl)-6-(Trifluoromethyl)-9-Phenanthrenemethanol Hydrochloride
  • 1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl
  • 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride
  • 1,3-Dichloro-alpha-(2-1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride
  • 1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride
  • 3-(Dibutylamino)-1-[1,3-Dichloro-6-(Trifluoromethyl)Phenanthren-9-Yl]Propan-1-Ol Hydrochloride (1:1)
  • 9-(3-(Dibutylamino)-1-Hydroxypropyl)-1,3-Dichloro-6-(Trifluoromethyl)Phenanthrene Hydrochloride
  • 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride
  • 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride
  • 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride (1:1)
  • See more synonyms
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Found 9 products.
  • CymitQuimica logo
    EDQM - European Pharmacopoeia
    + Info

    HALOFANTRINE HYDROCHLORIDE CRS

    CAS:
    HALOFANTRINE HYDROCHLORIDE CRS
    Formula:C26H31Cl3F3NO
    Color and Shape:White. Powder.
    Molecular weight:536.8846

    Ref: 41-Y0000117

    125mg
    115.00€
  • Halofantrine hydrochloride
    Indagoo
    + Info

    Halofantrine hydrochloride

    CAS:
    Formula:C26H31Cl3F3NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:536.8846

    Ref: IN-DA01AMSF

    5mg
    230.00€
    10mg
    566.00€
    125mg
    606.00€
  • Halofantrine hydrochloride
    Glentham
    + Info

    Halofantrine hydrochloride

    CAS:
    Formula:C26H30Cl2F3NO·HCl
    Molecular weight:536.88

    Ref: 7W-GL6107

    ne
    To inquire
  • CymitQuimica logo
    Apollo Scientific
    + Info

    Halofantrine hydrochloride

    CAS:
    Halofantrine hydrochloride
    Purity:≥95%
    Molecular weight:536.89g/mol

    Ref: 54-BUP22248

    1mg
    143.00€
  • Halofantrine hydrochloride
    Targetmol
    + Info

    Halofantrine hydrochloride

    CAS:
    Halofantrine hydrochloride (SKF-102886) is an orally administered antimalarial drug effective against drug-resistant P. falciparum and P. vivax. SKF-102886 has cardiac toxicity, inhibiting hERG and delayed rectifier potassium channel I Kr, leading to prolonged QTc and PR intervals.
    Formula:C26H31Cl3F3NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:536.89

    Ref: TM-T15460

  • Halofantrine Hydrochloride
    Mikromol
    + Info

    Halofantrine Hydrochloride

    Controlled Product
    CAS:
    Formula:C26H30Cl2F3NO·ClH
    Color and Shape:Neat
    Molecular weight:536.88

    Ref: 86-MM0433.00

    100mg
    To inquire
  • Halofantrine Hydrochloride
    LGC
    + Info

    Halofantrine Hydrochloride

    CAS:
    Color and Shape:Neat

    Ref: 61-FOR0433.00

    10mg
    232.00€
  • Halofantrine Hydrochloride
    TRC
    + Info

    Halofantrine Hydrochloride

    Controlled Product
    CAS:
    <p>Applications Antimalarial.<br>References Schmidt, L.H., et al.: Antimicrob. Agents Chemother., 14, 292 (1978), Hines, J.W., et al.: J. Pharm. Sci., 74, 433 (1985), Bryson, H.M., et al.: Drugs, 43, 236 (1992),<br></p>
    Formula:C26H30Cl2F3NO·ClH
    Color and Shape:Neat
    Molecular weight:536.88

    Ref: TR-H102400

    5mg
    142.00€
    10mg
    193.00€
    100mg
    1,370.00€
  • Halofantrine hydrochloride
    Biosynth
    + Info

    Halofantrine hydrochloride

    CAS:
    Halofantrine is a drug that belongs to the class of antimalarial drugs. It has been shown to be effective against the malaria parasite in vivo and in vitro. Halofantrine has been shown to have toxic effects on the skin, liver, and kidneys by inhibiting certain enzyme activities. This drug also causes autoimmune diseases and infectious diseases as well as cardiac effects, metabolic disorders, and serum prolactin levels. Halofantrine may have an effect on drug interactions with other medications. Halofantrine also causes a decrease in blood pressure due to its ability to reduce heart rate.
    Formula:C26H31Cl3F3NO
    Purity:Min. 95%
    Molecular weight:536.88 g/mol

    Ref: 3D-FH23729

    25mg
    863.00€