CAS 362-06-1

2-Hydroxyestrone

Description:

2-Hydroxyestrone is a naturally occurring estrogen and a metabolite of estrone, classified under the category of phenolic compounds. Its chemical formula is C18H22O3, and it features a hydroxyl group (-OH) at the second carbon position of the estrone structure, which contributes to its biological activity. This compound is known for its role in the regulation of various physiological processes, including reproductive functions and bone health. 2-Hydroxyestrone is often studied for its potential protective effects against certain hormone-dependent cancers, as it is believed to have weaker estrogenic activity compared to other estrogens. It is also involved in the metabolism of estrogens in the body, influencing the balance of estrogenic effects. In terms of physical properties, 2-Hydroxyestrone is typically a white to off-white crystalline powder, soluble in organic solvents, and exhibits stability under standard conditions. Its CAS number, 362-06-1, is used for identification in chemical databases and regulatory contexts.

Formula: C₁₈H₂₂O₃

InChI: InChI=1/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1

InChI key: InChIKey=SWINWPBPEKHUOD-JPVZDGGYSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=C(O)C4)(CC1)[H])[H])(CCC2=O)[H]

Synonyms:

• 2,3-Dihydroxyestra-1(10),2,4-Trien-17-One
• 2,3-Dihydroxyestra-1,3,5(10)-trien-17-one
• Catecholestrone
• Ccris 9276
• Estra-1,3,5(1)-trien-17-one, 2,3-dihydroxy-
• Estra-1,3,5(10)-trien-17-one, 2,3-dihydroxy-
• 2-Hydroxyestrone
• 1,3,5(10)Estatrien-2,3-diol-17-one
• 1,3,5[10]-ESTRATRIENE-2,3-DIOL-17-ONE
• 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE
• 2,3-Dihydroxy-1(10),2,4-estratriene-17-one
• 2,3-Dihydroxy-1(10),2,4-est
• 2,3-dihydroxy-estra-1,3,5(10)-trien-17-one

2-Hydroxyestrone 100 µg/mL in Acetonitrile

CAS: 362-06-1

Formula: C₁₈H₂₂O₃

Color and Shape: Single Solution

Molecular weight: 286.37

Ref: 04-A14231506AL-100

Estrone Impurity 6

CAS: 362-06-1

Formula: C₁₈H₂₂O₃

Molecular weight: 286.37

Ref: 4Z-E-1128

2-Hydroxy Estrone

Controlled Product

CAS: 362-06-1

Formula: C₁₈H₂₂O₃

Color and Shape: Off-White To Light Brown

Molecular weight: 286.37

Ref: TR-H941945

2-Hydroxy estrone

Controlled Product

CAS: 362-06-1

2-Hydroxy estrone is a metabolite of estradiol. It has been shown to be involved in the development of breast cancer and may be a biomarker for the disease. 2-Hydroxy estrone has been found to have genotoxic effects in experimental models and may cause DNA damage. It is also thought to play a role in regulating body weight, reproductive function, mood, and cognition. 2-Hydroxy estrone is an estrogen precursor that binds catechol-o-methyltransferase (COMT) and thereby inhibits COMT activity. This leads to increased levels of dopamine which contributes to breast cancer development. Experimental models have shown that 2-hydroxy estrone can induce tumours in mice by binding to estrogen receptors and stimulating cell division.

Formula: C₁₈H₂₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 286.37 g/mol

Ref: 3D-FH23994

2-Hydroxy Estrone

CAS: 362-06-1

Formula: C₁₈H₂₂O₃

Molecular weight: 286.4

Ref: ST-EA-CP-E28021